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Lovo-cel gene therapy for sickle cell disease: Treatment process evolution and outcomes in the initial groups of the HGB-206 study.
Kanter J, Thompson AA, Pierciey FJ Jr, Hsieh M, Uchida N, Leboulch P, Schmidt M, Bonner M, Guo R, Miller A, Ribeil JA, Davidson D, Asmal M, Walters MC, Tisdale JF. Kanter J, et al. Am J Hematol. 2023 Jan;98(1):11-22. doi: 10.1002/ajh.26741. Epub 2022 Oct 10. Am J Hematol. 2023. PMID: 36161320 Free PMC article.
The treatment process evolved over time, using learnings from outcomes in the initial patients to optimize lovo-cel's benefit-risk profile. Following modest expression of HbA(T87Q) in the initial patients (Group A, n = 7), alterations were made to the treatment process for …
The treatment process evolved over time, using learnings from outcomes in the initial patients to optimize lovo-cel's benefit-risk pr …
Resistance to coronavirus infection in amino peptidase N-deficient pigs.
Whitworth KM, Rowland RRR, Petrovan V, Sheahan M, Cino-Ozuna AG, Fang Y, Hesse R, Mileham A, Samuel MS, Wells KD, Prather RS. Whitworth KM, et al. Transgenic Res. 2019 Feb;28(1):21-32. doi: 10.1007/s11248-018-0100-3. Epub 2018 Oct 12. Transgenic Res. 2019. PMID: 30315482 Free PMC article.
A colorimetric broth microdilution method for assessment of Helicobacter pylori sensitivity to antimicrobial agents.
Knezevic P, Aleksic Sabo V, Simin N, Lesjak M, Mimica-Dukic N. Knezevic P, et al. J Pharm Biomed Anal. 2018 Apr 15;152:271-278. doi: 10.1016/j.jpba.2018.02.003. Epub 2018 Feb 8. J Pharm Biomed Anal. 2018. PMID: 29448222
After 3 day incubation, an equal volume of double strengthen Christensen's urea was added into each well and incubated for additional 4 h. In wells with present H. pylori, the medium changed color from yellow to purple, allowing MIC determination even without a micr …
After 3 day incubation, an equal volume of double strengthen Christensen's urea was added into each well and incubated for additional …
False positives in Biolog EcoPlates™ and MT2 MicroPlates™ caused by calcium.
Pierce ML, Ward JE, Dobbs FC. Pierce ML, et al. J Microbiol Methods. 2014 Feb;97:20-4. doi: 10.1016/j.mimet.2013.12.002. Epub 2013 Dec 11. J Microbiol Methods. 2014. PMID: 24333911
Experiments, in which multiple treatments of natural and artificial seawater were tested, as well as calcium-addition experiments, demonstrate that calcium inhibits complete dissolution of the minimal growth medium in wells. Future studies involving Biolog EcoPlates and Mi …
Experiments, in which multiple treatments of natural and artificial seawater were tested, as well as calcium-addition experiments, demonstra …
Groundwater contamination in coastal urban areas: Anthropogenic pressure and natural attenuation processes. Example of Recife (PE State, NE Brazil).
Bertrand G, Hirata R, Pauwels H, Cary L, Petelet-Giraud E, Chatton E, Aquilina L, Labasque T, Martins V, Montenegro S, Batista J, Aurouet A, Santos J, Bertolo R, Picot G, Franzen M, Hochreutener R, Braibant G. Bertrand G, et al. J Contam Hydrol. 2016 Sep;192:165-180. doi: 10.1016/j.jconhyd.2016.07.008. Epub 2016 Jul 26. J Contam Hydrol. 2016. PMID: 27500748
From a multi-tracer approach (major ions, major gases, delta(11)B, delta(18)O-SO4, delta(34)S-SO4) carried out during two field campaigns in September 2012 and March 2013 (sampling of 19 wells and 3 surface waters), it has been possible to assess the contamination s …
From a multi-tracer approach (major ions, major gases, delta(11)B, delta(18)O-SO4, delta(34)S-SO4) carried out during two field campa …
Metabolic parameters linked by phenotype microarray to acid resistance profiles of poultry-associated Salmonella enterica.
Guard J, Rothrock MJ, Shah DH, Jones DR, Gast RK, Sanchez-Ingunza R, Madsen M, El-Attrache J, Lungu B. Guard J, et al. Res Microbiol. 2016 Nov-Dec;167(9-10):745-756. doi: 10.1016/j.resmic.2016.06.006. Epub 2016 Jul 12. Res Microbiol. 2016. PMID: 27418207 Free article.
Datasets were partitioned initially into two clusters based on ranking by values at pH 4.5 (PM10 A03). Negative control wells were used to establish 90 respiratory units as the point differentiating acid resistance from sensitive strains. ...Statistical analyses of ranked …
Datasets were partitioned initially into two clusters based on ranking by values at pH 4.5 (PM10 A03). Negative control wells were us …
Natural attenuation of trichloroethylene in fractured shale bedrock.
Lenczewski M, Jardine P, McKay L, Layton A. Lenczewski M, et al. J Contam Hydrol. 2003 Jul;64(3-4):151-68. doi: 10.1016/S0169-7722(02)00090-6. J Contam Hydrol. 2003. PMID: 12814878
The monitoring well array consists of a 35-m-long transect of multilevel sampling wells, situated along a line between the waste pits and a seep which discharges into a small stream. Concentrations of volatile organic carbons (VOCs) were highest in the waste trenches and d …
The monitoring well array consists of a 35-m-long transect of multilevel sampling wells, situated along a line between the waste pits …