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Page 1
Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing.
Appelt J, Tsitsilonis S, Otto E, Jahn D, Köhli P, Baranowsky A, Jiang S, Fuchs M, Bucher CH, Duda GN, Frosch KH, Keller J. Appelt J, et al. Among authors: fuchs m. Cells. 2021 Sep 3;10(9):2304. doi: 10.3390/cells10092304. Cells. 2021. PMID: 34571953 Free PMC article.
Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment.
Baranowsky A, Jahn D, Jiang S, Yorgan T, Ludewig P, Appelt J, Albrecht KK, Otto E, Knapstein P, Donat A, Winneberger J, Rosenthal L, Köhli P, Erdmann C, Fuchs M, Frosch KH, Tsitsilonis S, Amling M, Schinke T, Keller J. Baranowsky A, et al. Among authors: fuchs m. Bone Res. 2022 Jan 27;10(1):9. doi: 10.1038/s41413-021-00172-y. Bone Res. 2022. PMID: 35087025 Free PMC article.
Increased beta2-adrenergic signaling is a targetable stimulus essential for bone healing by promoting callus neovascularization.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: fuchs m. bioRxiv [Preprint]. 2023 Jul 16:2023.07.14.548550. doi: 10.1101/2023.07.14.548550. bioRxiv. 2023. PMID: 37502964 Free PMC article. Preprint.
Increased β2-adrenergic signaling promotes fracture healing through callus neovascularization in mice.
Jahn D, Knapstein PR, Otto E, Köhli P, Sevecke J, Graef F, Graffmann C, Fuchs M, Jiang S, Rickert M, Erdmann C, Appelt J, Revend L, Küttner Q, Witte J, Rahmani A, Duda G, Xie W, Donat A, Schinke T, Ivanov A, Tchouto MN, Beule D, Frosch KH, Baranowsky A, Tsitsilonis S, Keller J. Jahn D, et al. Among authors: fuchs m. Sci Transl Med. 2024 Apr 17;16(743):eadk9129. doi: 10.1126/scitranslmed.adk9129. Epub 2024 Apr 17. Sci Transl Med. 2024. PMID: 38630849
The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing.
Appelt J, Baranowsky A, Jahn D, Yorgan T, Köhli P, Otto E, Farahani SK, Graef F, Fuchs M, Herrera A, Amling M, Schinke T, Frosch KH, Duda GN, Tsitsilonis S, Keller J. Appelt J, et al. Among authors: fuchs m. EBioMedicine. 2020 Sep;59:102970. doi: 10.1016/j.ebiom.2020.102970. Epub 2020 Aug 24. EBioMedicine. 2020. PMID: 32853990 Free PMC article.
The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.
Schweiger S, Dorn S, Fuchs M, Köhler A, Matthes F, Müller EC, Wanker E, Schneider R, Krauß S. Schweiger S, et al. Among authors: fuchs m. J Biol Chem. 2014 Nov 14;289(46):31805-31817. doi: 10.1074/jbc.M113.541219. Epub 2014 Oct 2. J Biol Chem. 2014. PMID: 25278022 Free PMC article.
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.
Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Kickstein E, et al. Among authors: fuchs m. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22. Proc Natl Acad Sci U S A. 2010. PMID: 21098287 Free PMC article.