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1993 1
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Page 1
MEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells.
Lee CS, Dykema KJ, Hawkins DM, Cherba DM, Webb CP, Furge KA, Duesbery NS. Lee CS, et al. PLoS One. 2011 Feb 18;6(2):e17165. doi: 10.1371/journal.pone.0017165. PLoS One. 2011. PMID: 21365009 Free PMC article.
Furthermore, LeTx efficiently inhibited the cell proliferation and anchorage-independent growth of SK-MEL-28 cells expressing MKK1cr but not MEK2cr. These results indicate in SK-MEL-28 cells MEK1 and MEK2 signaling pathways are not redundant and interchangeable for …
Furthermore, LeTx efficiently inhibited the cell proliferation and anchorage-independent growth of SK-MEL-28 cells expressing MKK1cr …
Results of a Randomized Controlled Multicenter Phase III Trial of Percutaneous Hepatic Perfusion Compared with Best Available Care for Patients with Melanoma Liver Metastases.
Hughes MS, Zager J, Faries M, Alexander HR, Royal RE, Wood B, Choi J, McCluskey K, Whitman E, Agarwala S, Siskin G, Nutting C, Toomey MA, Webb C, Beresnev T, Pingpank JF. Hughes MS, et al. Ann Surg Oncol. 2016 Apr;23(4):1309-19. doi: 10.1245/s10434-015-4968-3. Epub 2015 Nov 23. Ann Surg Oncol. 2016. PMID: 26597368 Free PMC article. Clinical Trial.

Median OS was not significantly different (PHP-Mel 10.6 months vs. BAC 10.0 months), likely due to crossover to PHP-Mel treatment (57.1 %) from the BAC arm, and the hOR was 36.4 % for PHP-Mel and 2.0 % for BAC (p < 0.001). The majority of adverse events we

…
Median OS was not significantly different (PHP-Mel 10.6 months vs. BAC 10.0 months), likely due to crossover to PHP-Mel treatm …
Optimization of antitumor modulators of pre-mRNA splicing.
Lagisetti C, Palacios G, Goronga T, Freeman B, Caufield W, Webb TR. Lagisetti C, et al. J Med Chem. 2013 Dec 27;56(24):10033-44. doi: 10.1021/jm401370h. Epub 2013 Dec 11. J Med Chem. 2013. PMID: 24325474 Free PMC article.
This optimization culminated in the discovery of sudemycin D6, which shows potent cytotoxic activity in the melanoma line SK-MEL-2 (IC50 = 39 nM) and other tumor cell lines, including JeKo-1 (IC50 = 22 nM), HeLa (IC50 = 50 nM), and SK-N-AS (IC50 = 81 nM). ...
This optimization culminated in the discovery of sudemycin D6, which shows potent cytotoxic activity in the melanoma line SK-MEL-2 (I …
Single-molecule analysis of subtelomeres and telomeres in Alternative Lengthening of Telomeres (ALT) cells.
Abid HZ, McCaffrey J, Raseley K, Young E, Lassahn K, Varapula D, Riethman H, Xiao M. Abid HZ, et al. BMC Genomics. 2020 Jul 15;21(1):485. doi: 10.1186/s12864-020-06901-7. BMC Genomics. 2020. PMID: 32669102 Free PMC article.
In eukaryotes lacking telomerase, a variety of DNA repair and DNA recombination based pathways for telomere maintenance have evolved in organisms normally dependent upon telomerase for telomere elongation (Webb CJ, Wu Y, Zakian VA; Cold Spring Harb Perspect Biol 5:a012666; …
In eukaryotes lacking telomerase, a variety of DNA repair and DNA recombination based pathways for telomere maintenance have evolved in orga …
A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells.
Saathoff H, Brofelth M, Trinh A, Parker BL, Ryan DP, Low JK, Webb SR, Silva AP, Mackay JP, Shepherd NE. Saathoff H, et al. Bioorg Med Chem. 2015 Mar 1;23(5):960-5. doi: 10.1016/j.bmc.2015.01.023. Epub 2015 Jan 22. Bioorg Med Chem. 2015. PMID: 25678017 Free article.
Loading this peptide onto Streptactin beads enabled capture of the intact NuRD complex from MEL cell nuclear extract. Gentle biotin elution yielded the desired intact complex free of significant contaminants and in a form that was catalytically competent in a nucleosome re …
Loading this peptide onto Streptactin beads enabled capture of the intact NuRD complex from MEL cell nuclear extract. Gentle biotin e …
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.
Richon VM, Webb Y, Merger R, Sheppard T, Jursic B, Ngo L, Civoli F, Breslow R, Rifkind RA, Marks PA. Richon VM, et al. Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5705-8. doi: 10.1073/pnas.93.12.5705. Proc Natl Acad Sci U S A. 1996. PMID: 8650156 Free PMC article.
Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of murine erythroleukemia (MEL) cells and a wide variety of other transformed cells. HMBA has been shown to induce differentiation of neoplastic cells …
Hybrid polar compounds, of which hexamethylenebisacetamide (HMBA) is the prototype, are potent inducers of differentiation of murine erythro …
Helplessness/hopelessness, minimization and optimism predict survival in women with invasive ovarian cancer: a role for targeted support during initial treatment decision-making?
Price MA, Butow PN, Bell ML, deFazio A, Friedlander M, Fardell JE, Protani MM, Webb PM; AOCS—Quality of Life Study Investigators on behalf of the Australian Ovarian Cancer Study Group. Price MA, et al. Support Care Cancer. 2016 Jun;24(6):2627-34. doi: 10.1007/s00520-015-3070-5. Epub 2016 Jan 6. Support Care Cancer. 2016. PMID: 26732767
Exclusion of circulating T cells from the thymus does not apply in the neonatal period.
Surh CD, Sprent J, Webb SR. Surh CD, et al. J Exp Med. 1993 Feb 1;177(2):379-85. doi: 10.1084/jem.177.2.379. J Exp Med. 1993. PMID: 8426109 Free PMC article.
The migration of resting T cells to the neonatal thymus is largely limited to an unusual subset of cells which lacks expression of the lymph node homing receptor, leukocyte-endothelial cell adhesion molecule 1 (LECAM-1) (MEL-14). Migration of mature T cells to the thymus i …
The migration of resting T cells to the neonatal thymus is largely limited to an unusual subset of cells which lacks expression of the lymph …
In vivo safety and antitumor efficacy of bifunctional small hairpin RNAs specific for the human Stathmin 1 oncoprotein.
Phadke AP, Jay CM, Wang Z, Chen S, Liu S, Haddock C, Kumar P, Pappen BO, Rao DD, Templeton NS, Daniels EQ, Webb C, Monsma D, Scott S, Dylewski D, Frieboes HB, Brunicardi FC, Senzer N, Maples PB, Nemunaitis J, Tong AW. Phadke AP, et al. DNA Cell Biol. 2011 Sep;30(9):715-26. doi: 10.1089/dna.2011.1240. Epub 2011 May 25. DNA Cell Biol. 2011. PMID: 21612405
Transfection with the bi-shSTMN1-encoding expression plasmid (pbi-shSTMN1) markedly reduced CCL-247 human colorectal cancer and SK-Mel-28 melanoma cell growth in vitro (Rao et al., 2010 ). We now examine in vivo the antitumor efficacy of this RNA interference-based approac …
Transfection with the bi-shSTMN1-encoding expression plasmid (pbi-shSTMN1) markedly reduced CCL-247 human colorectal cancer and SK-Mel …
A novel community health worker tool outperforms WHO clinical staging for assessment of antiretroviral therapy eligibility in a resource-limited setting.
Macpherson P, Lalloo DG, Thindwa D, Webb EL, Squire SB, Chipungu GA, Desmond N, Makombe SD, Taegtmeyer M, Choko AT, Corbett EL. Macpherson P, et al. J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):e74-8. doi: 10.1097/QAI.0b013e3182a20e74. J Acquir Immune Defic Syndr. 2014. PMID: 23846567 Free PMC article. Clinical Trial.
14 results