A Mathematical Model of Vaccinations Using New Fractional Order Derivative

Vaccines (Basel). 2022 Nov 22;10(12):1980. doi: 10.3390/vaccines10121980.

Abstract

Purpose: This paper studies a simple SVIR (susceptible, vaccinated, infected, recovered) type of model to investigate the coronavirus’s dynamics in Saudi Arabia with the recent cases of the coronavirus. Our purpose is to investigate coronavirus cases in Saudi Arabia and to predict the early eliminations as well as future case predictions. The impact of vaccinations on COVID-19 is also analyzed. Methods: We consider the recently introduced fractional derivative known as the generalized Hattaf fractional derivative to extend our COVID-19 model. To obtain the fitted and estimated values of the parameters, we consider the nonlinear least square fitting method. We present the numerical scheme using the newly introduced fractional operator for the graphical solution of the generalized fractional differential equation in the sense of the Hattaf fractional derivative. Mathematical as well as numerical aspects of the model are investigated. Results: The local stability of the model at disease-free equilibrium is shown. Further, we consider real cases from Saudi Arabia since 1 May−4 August 2022, to parameterize the model and obtain the basic reproduction number R0v≈2.92. Further, we find the equilibrium point of the endemic state and observe the possibility of the backward bifurcation for the model and present their results. We present the global stability of the model at the endemic case, which we found to be globally asymptotically stable when R0v>1. Conclusion: The simulation results using the recently introduced scheme are obtained and discussed in detail. We present graphical results with different fractional orders and found that when the order is decreased, the number of cases decreases. The sensitive parameters indicate that future infected cases decrease faster if face masks, social distancing, vaccination, etc., are effective.

Keywords: backward bifurcation; generalized fractional derivative; numerical results; real cases.

Grants and funding

This work was supported by the Deanship of Scientific Research at King Khalid University, Abha, Saudi Arabia through Small Groups project under grant number RGP.1/227/43.