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Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.
Griesemer D, Xue JR, Reilly SK, Ulirsch JC, Kukreja K, Davis JR, Kanai M, Yang DK, Butts JC, Guney MH, Luban J, Montgomery SB, Finucane HK, Novina CD, Tewhey R, Sabeti PC. Griesemer D, et al. Among authors: guney mh. Cell. 2021 Sep 30;184(20):5247-5260.e19. doi: 10.1016/j.cell.2021.08.025. Epub 2021 Sep 16. Cell. 2021. PMID: 34534445 Free PMC article.
The HIV-1 capsid core is an opportunistic nuclear import receptor.
Xue G, Yu HJ, Buffone C, Huang SW, Lee K, Goh SL, Gres AT, Guney MH, Sarafianos SG, Luban J, Diaz-Griffero F, KewalRamani VN. Xue G, et al. Nat Commun. 2023 Jun 24;14(1):3782. doi: 10.1038/s41467-023-39146-5. Nat Commun. 2023. PMID: 37355754 Free PMC article.
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
Fukuda K, Okamura K, Riding RL, Fan X, Afshari K, Haddadi NS, McCauley SM, Guney MH, Luban J, Funakoshi T, Yaguchi T, Kawakami Y, Khvorova A, Fitzgerald KA, Harris JE. Fukuda K, et al. Among authors: guney mh. J Exp Med. 2021 Sep 6;218(9):e20200962. doi: 10.1084/jem.20200962. Epub 2021 Jul 29. J Exp Med. 2021. PMID: 34325468 Free PMC article.