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Page 1
Schistosome Sulfotransferases: Mode of Action, Expression and Localization.
Pharmaceutics. 2022 Jul 6;14(7):1416. doi: 10.3390/pharmaceutics14071416.
Pharmaceutics. 2022.
PMID: 35890311
Free PMC article.
An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans.
Guzman MA, Rugel AR, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy DP, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF, LoVerde PT.
Guzman MA, et al.
PLoS Negl Trop Dis. 2020 Aug 18;14(8):e0008517. doi: 10.1371/journal.pntd.0008517. eCollection 2020 Aug.
PLoS Negl Trop Dis. 2020.
PMID: 32810153
Free PMC article.
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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?
Rugel AR, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ, LoVerde PT.
Rugel AR, et al. Among authors: guzman ma.
Int J Parasitol Drugs Drug Resist. 2020 Aug;13:8-15. doi: 10.1016/j.ijpddr.2020.04.001. Epub 2020 Apr 10.
Int J Parasitol Drugs Drug Resist. 2020.
PMID: 32315953
Free PMC article.
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Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents.
Rugel A, Tarpley RS, Lopez A, Menard T, Guzman MA, Taylor AB, Cao X, Kovalskyy D, Chevalier FD, Anderson TJC, Hart PJ, LoVerde PT, McHardy SF.
Rugel A, et al. Among authors: guzman ma.
ACS Med Chem Lett. 2018 Sep 14;9(10):967-973. doi: 10.1021/acsmedchemlett.8b00257. eCollection 2018 Oct 11.
ACS Med Chem Lett. 2018.
PMID: 30344901
Free PMC article.
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Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment.
Chevalier FD, Le Clec'h W, McDew-White M, Menon V, Guzman MA, Holloway SP, Cao X, Taylor AB, Kinung'hi S, Gouvras AN, Webster BL, Webster JP, Emery AM, Rollinson D, Garba Djirmay A, Al Mashikhi KM, Al Yafae S, Idris MA, Moné H, Mouahid G, Hart PJ, LoVerde PT, Anderson TJC.
Chevalier FD, et al. Among authors: guzman ma.
PLoS Pathog. 2019 Oct 25;15(10):e1007881. doi: 10.1371/journal.ppat.1007881. eCollection 2019 Oct.
PLoS Pathog. 2019.
PMID: 31652296
Free PMC article.
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