Doppler-based flow rate sensing in microfluidic channels

Sensors (Basel). 2014 Sep 10;14(9):16799-807. doi: 10.3390/s140916799.

Abstract

We design, fabricate and experimentally demonstrate a novel generic method to detect flow rates and precise changes of flow velocity in microfluidic devices. Using our method we can measure flow rates of ~2 mm/s with a resolution of 0.08 mm/s. The operation principle is based on the Doppler shifting of light diffracted from a self-generated periodic array of bubbles within the channel and using self-heterodyne detection to analyze the diffracted light. As such, the device is appealing for variety of "lab on chip" bio-applications where a simple and accurate speed measurement is needed, e.g., for flow-cytometry and cell sorting.

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Laser-Doppler Flowmetry / instrumentation*
  • Microfluidic Analytical Techniques / instrumentation*
  • Miniaturization