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Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors.
J Pharmacol Exp Ther. 2010 Sep 1;334(3):720-8. doi: 10.1124/jpet.110.167908. Epub 2010 Jun 11.
J Pharmacol Exp Ther. 2010.
PMID: 20543096
Free PMC article.
Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity.
Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L.
Popova M, et al.
Int J Mol Sci. 2020 Apr 2;21(7):2471. doi: 10.3390/ijms21072471.
Int J Mol Sci. 2020.
PMID: 32252459
Free PMC article.
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Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.
Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L.
Popova M, et al.
Purinergic Signal. 2013 Dec;9(4):621-32. doi: 10.1007/s11302-013-9373-4. Epub 2013 Jul 2.
Purinergic Signal. 2013.
PMID: 23817978
Free PMC article.
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Ethanol is a fast channel inhibitor of P2X4 receptors.
Ostrovskaya O, Asatryan L, Wyatt L, Popova M, Li K, Peoples RW, Alkana RL, Davies DL.
Ostrovskaya O, et al. Among authors: popova m.
J Pharmacol Exp Ther. 2011 Apr;337(1):171-9. doi: 10.1124/jpet.110.176990. Epub 2011 Jan 6.
J Pharmacol Exp Ther. 2011.
PMID: 21212160
Free PMC article.
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A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.
Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL, Davies DL.
Popova M, et al.
J Neurochem. 2010 Jan;112(1):307-17. doi: 10.1111/j.1471-4159.2009.06460.x. Epub 2009 Oct 28.
J Neurochem. 2010.
PMID: 19878433
Free PMC article.
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Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors.
Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL.
Asatryan L, et al. Among authors: popova m.
Neuropharmacology. 2008 Oct;55(5):835-43. doi: 10.1016/j.neuropharm.2008.06.044. Epub 2008 Jun 29.
Neuropharmacology. 2008.
PMID: 18639563
Free PMC article.
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