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1999 1
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2023 1
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Page 1
Impact of first-line use of caplacizumab on treatment outcomes in immune thrombotic thrombocytopenic purpura.
Völker LA, Kaufeld J, Balduin G, Merkel L, Kühne L, Eichenauer DA, Osterholt T, Hägele H, Kann M, Grundmann F, Kolbrink B, Schulte K, Gäckler A, Kribben A, Boss K, Potthoff SA, Rump LC, Schmidt T, Mühlfeld AS, Schulmann K, Hermann M, Gaedeke J, Sauerland K, Bramstedt J, Hinkel UP, Miesbach W, Bauer F, Westhoff TH, Bruck H, Buxhofer-Ausch V, Müller TJ, Wendt R, Harth A, Schreiber A, Seelow E, Tölle M, Gohlisch C, Bieringer M, Geuther G, Jabs WJ, Fischereder M, von Bergwelt-Baildon A, Schönermarck U, Knoebl P, Menne J, Brinkkoetter PT; German TTP-Study Group. Völker LA, et al. J Thromb Haemost. 2023 Mar;21(3):559-572. doi: 10.1016/j.jtha.2022.11.010. Epub 2022 Dec 22. J Thromb Haemost. 2023. PMID: 36696206 Free article.
Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting.
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Biglari N, et al. Nat Neurosci. 2021 Jul;24(7):913-929. doi: 10.1038/s41593-021-00854-0. Epub 2021 May 17. Nat Neurosci. 2021. PMID: 34002087 Free PMC article.
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.
De Solis AJ, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder CA, Eggersmann FR, Morgan DA, Cremer AL, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning JC. De Solis AJ, et al. Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20. Nat Metab. 2024. PMID: 38378998 Free PMC article.
Cardiac Effects of Hyperoxia During Resuscitation From Hemorrhagic Shock in Swine.
Datzmann T, Wepler M, Wachter U, Vogt JA, McCook O, Merz T, Calzia E, Gröger M, Hartmann C, Asfar P, Radermacher P, Nussbaum BL. Datzmann T, et al. Shock. 2019 Oct;52(4):e52-e59. doi: 10.1097/SHK.0000000000001283. Shock. 2019. PMID: 30407373
At 48 h, cardiac tissue was harvested for western blotting, immunohistochemistry, and mitochondrial respiration.Except for higher left ventricular end-diastolic pressures at 24 h (hyperoxia 21 (17;24), control 17 (15;18) mm Hg; P = 0.046), hyperoxia affected neither left ventricu …
At 48 h, cardiac tissue was harvested for western blotting, immunohistochemistry, and mitochondrial respiration.Except for higher left ventr …
Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption.
Crokart N, Jordan BF, Baudelet C, Cron GO, Hotton J, Radermacher K, Grégoire V, Beghein N, Martinive P, Bouzin C, Feron O, Gallez B. Crokart N, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):630-5. doi: 10.1158/1078-0432.CCR-06-0802. Clin Cancer Res. 2007. PMID: 17255286 Free article.
RESULTS: All glucocorticoids tested caused a rapid increase in pO(2). At t(max), tumor perfusion decreased, indicating that the increase in pO(2) was not caused by an increase in oxygen supply. Also at t(max), global oxygen consumption decreased. When irradiation (2 …
RESULTS: All glucocorticoids tested caused a rapid increase in pO(2). At t(max), tumor perfusion decreased, indicating that the incre …
Real-world data confirm the effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura.
Völker LA, Kaufeld J, Miesbach W, Brähler S, Reinhardt M, Kühne L, Mühlfeld A, Schreiber A, Gaedeke J, Tölle M, Jabs WJ, Özcan F, Markau S, Girndt M, Bauer F, Westhoff TH, Felten H, Hausberg M, Brand M, Gerth J, Bieringer M, Bommer M, Zschiedrich S, Schneider J, Elitok S, Gawlik A, Gäckler A, Kribben A, Schwenger V, Schoenermarck U, Roeder M, Radermacher J, Bramstedt J, Morgner A, Herbst R, Harth A, Potthoff SA, von Auer C, Wendt R, Christ H, Brinkkoetter PT, Menne J. Völker LA, et al. Blood Adv. 2020 Jul 14;4(13):3085-3092. doi: 10.1182/bloodadvances.2020001973. Blood Adv. 2020. PMID: 32634236 Free PMC article.
ADAMTS13 and VWF activities guide individualized caplacizumab treatment in patients with aTTP.
Völker LA, Kaufeld J, Miesbach W, Brähler S, Reinhardt M, Kühne L, Mühlfeld A, Schreiber A, Gaedeke J, Tölle M, Jabs WJ, Özcan F, Markau S, Girndt M, Bauer F, Westhoff TH, Felten H, Hausberg M, Brand M, Gerth J, Bieringer M, Bommer M, Zschiedrich S, Schneider J, Elitok S, Gawlik A, Gäckler A, Kribben A, Schwenger V, Schoenermarck U, Roeder M, Radermacher J, Bramstedt J, Morgner A, Herbst R, Harth A, Potthoff SA, von Auer C, Wendt R, Christ H, Brinkkoetter PT, Menne J. Völker LA, et al. Blood Adv. 2020 Jul 14;4(13):3093-3101. doi: 10.1182/bloodadvances.2020001987. Blood Adv. 2020. PMID: 32634237 Free PMC article.
Tumor radiosensitization by antiinflammatory drugs: evidence for a new mechanism involving the oxygen effect.
Crokart N, Radermacher K, Jordan BF, Baudelet C, Cron GO, Grégoire V, Beghein N, Bouzin C, Feron O, Gallez B. Crokart N, et al. Cancer Res. 2005 Sep 1;65(17):7911-6. doi: 10.1158/0008-5472.CAN-05-1288. Cancer Res. 2005. PMID: 16140962
Also at t(max), global oxygen consumption decreased but the amount of tumor-infiltrating macrophages remained unchanged. Our study strongly indicates that the oxygen effect caused by NSAIDs is primarily mediated by an effect on mitochondrial respiration. When irradiation ( …
Also at t(max), global oxygen consumption decreased but the amount of tumor-infiltrating macrophages remained unchanged. Our study st …
Effect of SOD-1 over-expression on myocardial function during resuscitated murine septic shock.
Baumgart K, Simkova V, Wagner F, Weber S, Georgieff M, Radermacher P, Albuszies G, Barth E. Baumgart K, et al. Intensive Care Med. 2009 Feb;35(2):344-9. doi: 10.1007/s00134-008-1319-x. Epub 2008 Oct 15. Intensive Care Med. 2009. PMID: 18854975
Anesthesia and fluid resuscitation alone caused left ventricular dilatation and a progressive fall in left ventricular end-systolic pressure and maximal systolic contraction (dp/dt (max)), while stroke volume and cardiac output increased. Due to the noradrenaline infusion …
Anesthesia and fluid resuscitation alone caused left ventricular dilatation and a progressive fall in left ventricular end-systolic pressure …
17 results