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Page 1
Determinants of telomere length across human tissues.
Demanelis K, Jasmine F, Chen LS, Chernoff M, Tong L, Delgado D, Zhang C, Shinkle J, Sabarinathan M, Lin H, Ramirez E, Oliva M, Kim-Hellmuth S, Stranger BE, Lai TP, Aviv A, Ardlie KG, Aguet F, Ahsan H; GTEx Consortium; Doherty JA, Kibriya MG, Pierce BL. Demanelis K, et al. Science. 2020 Sep 11;369(6509):eaaz6876. doi: 10.1126/science.aaz6876. Science. 2020. PMID: 32913074 Free PMC article.
The effect of potent CYP2D6 inhibition on the pharmacokinetics and safety of deutetrabenazine in healthy volunteers.
Schneider F, Stamler D, Bradbury MJ, Loupe PS, Gordon MF, Rabinovich-Guilatt L. Schneider F, et al. Eur J Clin Pharmacol. 2022 Jan;78(1):11-18. doi: 10.1007/s00228-021-03202-0. Epub 2021 Sep 1. Eur J Clin Pharmacol. 2022. PMID: 34491372 Free PMC article. Clinical Trial.
RESULTS: Paroxetine administered under steady-state conditions, increased exposure of the deuterated active metabolites, alpha-HTBZ (1.2-fold C(max) and 1.8-fold AUC(0-)) and beta-HTBZ (2.1-fold C(max) and 5.6-fold AUC(0-)), and correspondingly, 1.6-fo …
RESULTS: Paroxetine administered under steady-state conditions, increased exposure of the deuterated active metabolites, alpha-HTBZ (1.2-fol …
Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect.
Schneider F, Stamler D, Bradbury M, Loupe PS, Hellriegel E, Cox DS, Savola JM, Gordon MF, Rabinovich-Guilatt L. Schneider F, et al. Clin Pharmacol Drug Dev. 2021 Jun;10(6):647-659. doi: 10.1002/cpdd.882. Epub 2020 Oct 10. Clin Pharmacol Drug Dev. 2021. PMID: 33038289 Free PMC article. Clinical Trial.
Food had no effect on exposure to total (alpha+beta)-HTBZ, as measured by AUC. Although the total (alpha+beta)-HTBZ C(max) of deutetrabenazine was increased by 50% in the presence of food, it remained lower than that of tetrabenazine....
Food had no effect on exposure to total (alpha+beta)-HTBZ, as measured by AUC. Although the total (alpha+beta)-HTBZ C(max) of …
Pharmacokinetic and Metabolic Profile of Deutetrabenazine (TEV-50717) Compared With Tetrabenazine in Healthy Volunteers.
Schneider F, Bradbury M, Baillie TA, Stamler D, Hellriegel E, Cox DS, Loupe PS, Savola JM, Rabinovich-Guilatt L. Schneider F, et al. Clin Transl Sci. 2020 Jul;13(4):707-717. doi: 10.1111/cts.12754. Epub 2020 Mar 10. Clin Transl Sci. 2020. PMID: 32155315 Free PMC article. Clinical Trial.
In the two-way, cross-over study, the mean elimination half-life of deuterated total (alpha + beta)-HTBZ was doubled compared with nondeuterated total (alpha + beta)-HTBZ, with a twofold increase in overall mean exposure (area under the concentration-time curve from zero to infin …
In the two-way, cross-over study, the mean elimination half-life of deuterated total (alpha + beta)-HTBZ was doubled compared with nondeuter …
Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects.
Schneider F, Erisson L, Beygi H, Bradbury M, Cohen-Barak O, Grachev ID, Guzy S, Loupe PS, Levi M, McDonald M, Savola JM, Papapetropoulos S, Tracewell WG, Velinova M, Spiegelstein O. Schneider F, et al. Br J Clin Pharmacol. 2018 Oct;84(10):2422-2432. doi: 10.1111/bcp.13702. Epub 2018 Aug 9. Br J Clin Pharmacol. 2018. PMID: 29959802 Free PMC article. Clinical Trial.
RESULTS: Geometric least squares mean ratios (GMRs) and 90% confidence intervals (90% CI) of SD-1077 vs. L-DOPA for C(max) , AUC(0-t) , and AUC(0-inf) were 88.4 (75.9-103.1), 89.5 (84.1-95.3), and 89.6 (84.2-95.4), respectively. ...There were increases in systemic e …
RESULTS: Geometric least squares mean ratios (GMRs) and 90% confidence intervals (90% CI) of SD-1077 vs. L-DOPA for C(max) , A …
Genome-wide association of carbon and nitrogen metabolism in the maize nested association mapping population.
Zhang N, Gibon Y, Wallace JG, Lepak N, Li P, Dedow L, Chen C, So YS, Kremling K, Bradbury PJ, Brutnell T, Stitt M, Buckler ES. Zhang N, et al. Plant Physiol. 2015 Jun;168(2):575-83. doi: 10.1104/pp.15.00025. Epub 2015 Apr 27. Plant Physiol. 2015. PMID: 25918116 Free PMC article.
Carbon (C) and nitrogen (N) metabolism are critical to plant growth and development and are at the basis of crop yield and adaptation. We performed high-throughput metabolite analyses on over 12,000 samples from the nested association mapping population to identify genetic …
Carbon (C) and nitrogen (N) metabolism are critical to plant growth and development and are at the basis of crop yield and adaptation …
Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B/Pl rats in response to high-fat diets.
Petrescu O, Cheema AF, Fan X, Bradbury MW, Berk PD. Petrescu O, et al. Int J Obes (Lond). 2008 May;32(5):853-62. doi: 10.1038/sj.ijo.0803792. Epub 2008 Jan 15. Int J Obes (Lond). 2008. PMID: 18197182
It was normalized in S by days 6-9 but persisted at least till day 14 in OM. RWGs were significantly correlated (P<0.001) with the V(max) for saturable adipocyte LCFA uptake (V(max)). In S, an increase in V(max) on day 1 returned to baseline by day 7 and w …
It was normalized in S by days 6-9 but persisted at least till day 14 in OM. RWGs were significantly correlated (P<0.001) with the V(m …
First description of two moderately halophilic and psychrotolerant Mycoplasma species isolated from cephalopods and proposal of Mycoplasma marinum sp. nov. and Mycoplasma todarodis sp. nov.
Ramírez AS, Vega-Orellana OM, Viver T, Poveda JB, Rosales RS, Poveda CG, Spergser J, Szostak MP, Caballero MJ, Ressel L, Bradbury JM, Mar Tavío M, Karthikeyan S, Amann R, Konstantinidis KT, Rossello-Mora R. Ramírez AS, et al. Syst Appl Microbiol. 2019 Jul;42(4):457-467. doi: 10.1016/j.syapm.2019.04.003. Epub 2019 Apr 12. Syst Appl Microbiol. 2019. PMID: 31072660
Three strains were isolated in pure culture from two individual European flying squid (Todarodes sagittatus), and two individual octopuses (Octopus vulgaris). The strains showed optimal growth at 25 C and a salinity of 3% (w/v) NaCl. Molecular analyses revealed that the is …
Three strains were isolated in pure culture from two individual European flying squid (Todarodes sagittatus), and two individual octopuses ( …
Erratum to "First description of two moderately halophilic and psychrotolerant Mycoplasma species isolated from cephalopods and proposal of Mycoplasma marinum sp. nov. and Mycoplasma todarod is sp. nov" [Syst. Appl. Microbiol. 42 (2019) 457-467].
Ramírez AS, Vega-Orellana OM, Viver T, Poveda JB, Rosales RS, Poveda CG, Spergser J, Szostak MP, Caballero MJ, Ressel L, Bradbury JM, Tavío MM, Karthikeyan S, Amann R, Konstantinidis KT, Rosselló-Móra R. Ramírez AS, et al. Syst Appl Microbiol. 2020 Jan;43(1):126027. doi: 10.1016/j.syapm.2019.126027. Epub 2019 Nov 4. Syst Appl Microbiol. 2020. PMID: 31699460 No abstract available.
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA. Anderson JJ, et al. J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51. doi: 10.1124/jpet.102.040618. J Pharmacol Exp Ther. 2002. PMID: 12438526
The binding of [3H]methoxymethyl-MTEP was of high affinity (K(d) = 20 +/- 2.7 nM), saturable (B(max) = 487 +/- 48 fmol/mg protein), and to a single site. The mGlu5 antagonists methoxymethyl-MTEP and MPEP displaced [3H]methoxymethyl-MTEP binding with IC50 values of 30 and 1 …
The binding of [3H]methoxymethyl-MTEP was of high affinity (K(d) = 20 +/- 2.7 nM), saturable (B(max) = 487 +/- 48 fmol/mg protein), a …