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Showing results for matthieu matures
Your search for Matthieu Maures retrieved no results
Targeted protein degradation: expanding the toolbox.
Schapira M, Calabrese MF, Bullock AN, Crews CM. Schapira M, et al. Nat Rev Drug Discov. 2019 Dec;18(12):949-963. doi: 10.1038/s41573-019-0047-y. Epub 2019 Oct 30. Nat Rev Drug Discov. 2019. PMID: 31666732
Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system represent a new therapeutic modality and are the focus of great interest, owing to potential advantages over traditional occupancy-based inhi …
Proteolysis-targeting chimeras (PROTACs) and related molecules that induce targeted protein degradation by the ubiquitin-proteasome system r …
Methods for computer-assisted PROTAC design.
Rovers E, Schapira M. Rovers E, et al. Methods Enzymol. 2023;690:311-340. doi: 10.1016/bs.mie.2023.06.020. Epub 2023 Jul 21. Methods Enzymol. 2023. PMID: 37858533 Review.
Proximity-induced pharmacology is an emerging field in chemical biology and drug discovery where a small molecule induces non-natural interactions between two proteins, leading to specific phenotypic responses. Proteolysis targeting chimeras (PROTACs) are the most mature e …
Proximity-induced pharmacology is an emerging field in chemical biology and drug discovery where a small molecule induces non-natural intera …
SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals.
Sokal A, Barba-Spaeth G, Hunault L, Fernández I, Broketa M, Meola A, Fourati S, Azzaoui I, Vandenberghe A, Lagouge-Roussey P, Broutin M, Roeser A, Bouvier-Alias M, Crickx E, Languille L, Fournier M, Michel M, Godeau B, Gallien S, Melica G, Nguyen Y, Canoui-Poitrine F, Pirenne F, Megret J, Pawlotsky JM, Fillatreau S, Reynaud CA, Weill JC, Rey FA, Bruhns P, Mahévas M, Chappert P. Sokal A, et al. Immunity. 2023 Sep 12;56(9):2137-2151.e7. doi: 10.1016/j.immuni.2023.07.007. Epub 2023 Aug 4. Immunity. 2023. PMID: 37543032
How infection by a viral variant showing antigenic drift impacts a preformed mature human memory B cell (MBC) repertoire remains an open question. ...Reorganization of clonal hierarchy and new rounds of germinal center reactions, however, combined to maintain diversity and …
How infection by a viral variant showing antigenic drift impacts a preformed mature human memory B cell (MBC) repertoire remains an o …
25th Annual Computational Neuroscience Meeting: CNS-2016.
Sharpee TO, Destexhe A, Kawato M, Sekulić V, Skinner FK, Wójcik DK, Chintaluri C, Cserpán D, Somogyvári Z, Kim JK, Kilpatrick ZP, Bennett MR, Josić K, Elices I, Arroyo D, Levi R, Rodriguez FB, Varona P, Hwang E, Kim B, Han HB, Kim T, McKenna JT, Brown RE, McCarley RW, Choi JH, Rankin J, Popp PO, Rinzel J, Tabas A, Rupp A, Balaguer-Ballester E, Maturana MI, Grayden DB, Cloherty SL, Kameneva T, Ibbotson MR, Meffin H, Koren V, Lochmann T, Dragoi V, Obermayer K, Psarrou M, Schilstra M, Davey N, Torben-Nielsen B, Steuber V, Ju H, Yu J, Hines ML, Chen L, Yu Y, Kim J, Leahy W, Shlizerman E, Birgiolas J, Gerkin RC, Crook SM, Viriyopase A, Memmesheimer RM, Gielen S, Dabaghian Y, DeVito J, Perotti L, Kim AJ, Fenk LM, Cheng C, Maimon G, Zhao C, Widmer Y, Sprecher S, Senn W, Halnes G, Mäki-Marttunen T, Keller D, Pettersen KH, Andreassen OA, Einevoll GT, Yamada Y, Steyn-Ross ML, Alistair Steyn-Ross D, Mejias JF, Murray JD, Kennedy H, Wang XJ, Kruscha A, Grewe J, Benda J, Lindner B, Badel L, Ohta K, Tsuchimoto Y, Kazama H, Kahng B, Tam ND, Pollonini L, Zouridakis G, Soh J, Kim D, Yoo M, Palmer SE, Culmone V, Bojak I, Ferrario A, Merrison-Hort R, Borisyuk R, Kim CS, Tezuka T, Joo P, Rho YA, Burt… See abstract for full author list ➔ Sharpee TO, et al. BMC Neurosci. 2016 Aug 18;17 Suppl 1(Suppl 1):54. doi: 10.1186/s12868-016-0283-6. BMC Neurosci. 2016. PMID: 27534393 Free PMC article.
Schiff P68 STDP improves speech recognition capabilities in spiking recurrent circuits parameterized via differential evolution Markov Chain Monte Carlo Richard Veale, Matthias Scheutz P69 Bidirectional transformation between dominant cortical neural activities and phase differen …
Schiff P68 STDP improves speech recognition capabilities in spiking recurrent circuits parameterized via differential evolution Markov Chain …
Calcium signaling in Xenopus oocyte.
Marin M. Marin M. Adv Exp Med Biol. 2012;740:1073-94. doi: 10.1007/978-94-007-2888-2_49. Adv Exp Med Biol. 2012. PMID: 22453984 Review.
The understanding of the role of calcium during oocyte oogenesis, maturation and fertilization is facilitated by the big size of the cell but also by using imaging and electrophysiological approaches. ...Moreover, it will help us to understand the several reorganizations h …
The understanding of the role of calcium during oocyte oogenesis, maturation and fertilization is facilitated by the big size of the …
Delivering the power of nanomedicine to patients today.
Germain M, Caputo F, Metcalfe S, Tosi G, Spring K, Åslund AKO, Pottier A, Schiffelers R, Ceccaldi A, Schmid R. Germain M, et al. J Control Release. 2020 Oct 10;326:164-171. doi: 10.1016/j.jconrel.2020.07.007. Epub 2020 Jul 15. J Control Release. 2020. PMID: 32681950 Free PMC article. Review.
This ETPN overview of achievements in nanomedicine serves to reinforce our drive towards further expanding and growing the maturity of nanomedicine for global healthcare, accelerating the pace of transformation of its great potential into tangible medical breakthroughs....
This ETPN overview of achievements in nanomedicine serves to reinforce our drive towards further expanding and growing the maturity o …
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.
Sokal A, Chappert P, Barba-Spaeth G, Roeser A, Fourati S, Azzaoui I, Vandenberghe A, Fernandez I, Meola A, Bouvier-Alias M, Crickx E, Beldi-Ferchiou A, Hue S, Languille L, Michel M, Baloul S, Noizat-Pirenne F, Luka M, Mégret J, Ménager M, Pawlotsky JM, Fillatreau S, Rey FA, Weill JC, Reynaud CA, Mahévas M. Sokal A, et al. Cell. 2021 Mar 4;184(5):1201-1213.e14. doi: 10.1016/j.cell.2021.01.050. Epub 2021 Feb 2. Cell. 2021. PMID: 33571429 Free PMC article.
While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, mem …
While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in …
Prepubertal gonad investment modulates thymus function: evidence in a teleost fish.
Paiola M, Moreira C, Hétru J, Duflot A, Pinto PIS, Scapigliati G, Knigge T, Monsinjon T. Paiola M, et al. J Exp Biol. 2021 Mar 31;224(Pt 7):jeb238576. doi: 10.1242/jeb.238576. J Exp Biol. 2021. PMID: 33789987
Comparing fixed and variable environmental conditions, our work also demonstrates that the extent of the effects on the thymus, which are related to reproduction, depend on ecophysiological conditions, rather than being directly related to sexual maturity and sex hormone l …
Comparing fixed and variable environmental conditions, our work also demonstrates that the extent of the effects on the thymus, which are re …
Modulatory effects of pheromone on olfactory learning and memory in moths.
Murmu MS, Hanoune J, Choi A, Bureau V, Renou M, Dacher M, Deisig N. Murmu MS, et al. J Insect Physiol. 2020 Nov-Dec;127:104159. doi: 10.1016/j.jinsphys.2020.104159. Epub 2020 Oct 27. J Insect Physiol. 2020. PMID: 33127358 Free article.
To test this hypothesis, we studied the possible modulatory effects of pheromones on olfactory learning and memory in Agrotis ipsilon moths, which are well-established models to study sex-pheromones. To achieve this, sexually mature male moths were trained to associate an …
To test this hypothesis, we studied the possible modulatory effects of pheromones on olfactory learning and memory in Agrotis ipsilon moths, …
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Sokal A, Barba-Spaeth G, Fernández I, Broketa M, Azzaoui I, de La Selle A, Vandenberghe A, Fourati S, Roeser A, Meola A, Bouvier-Alias M, Crickx E, Languille L, Michel M, Godeau B, Gallien S, Melica G, Nguyen Y, Zarrouk V, Canoui-Poitrine F, Pirenne F, Mégret J, Pawlotsky JM, Fillatreau S, Bruhns P, Rey FA, Weill JC, Reynaud CA, Chappert P, Mahévas M. Sokal A, et al. Immunity. 2021 Dec 14;54(12):2893-2907.e5. doi: 10.1016/j.immuni.2021.09.011. Epub 2021 Sep 21. Immunity. 2021. PMID: 34614412 Free PMC article.
Upon boosting, the MBC pool of recovered individuals expanded selectively, matured further, and harbored potent neutralizers against VOCs. Although naive individuals had weaker neutralizing serum responses, half of their RBD-specific MBCs displayed high affinity toward mul …
Upon boosting, the MBC pool of recovered individuals expanded selectively, matured further, and harbored potent neutralizers against …
43 results