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Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection.
Int J Mol Sci. 2022 Jun 30;23(13):7271. doi: 10.3390/ijms23137271.
Int J Mol Sci. 2022.
PMID: 35806279
Free PMC article.
The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37.
Kowallik S, Kritikos A, Kästle M, Thurm C, Schraven B, Simeoni L.
Kowallik S, et al. Among authors: kastle m.
Int J Mol Sci. 2020 Dec 24;22(1):126. doi: 10.3390/ijms22010126.
Int J Mol Sci. 2020.
PMID: 33374422
Free PMC article.
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Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions.
Kästle M, Merten C, Hartig R, Kaehne T, Liaunardy-Jopeace A, Woessner NM, Schamel WW, James J, Minguet S, Simeoni L, Schraven B.
Kästle M, et al.
Cell Commun Signal. 2020 Nov 23;18(1):183. doi: 10.1186/s12964-020-00673-z.
Cell Commun Signal. 2020.
PMID: 33225946
Free PMC article.
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De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.
Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.
Philipsen L, et al. Among authors: kastle m.
Sci Signal. 2017 Jan 17;10(462):eaaf4736. doi: 10.1126/scisignal.aaf4736.
Sci Signal. 2017.
PMID: 28096507
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