First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B

Matthias Lotter; Johannes Schilling; Eberhard Reimann; Franz Bracher

doi:10.1002/ardp.200600134

First total synthesis of the 2,7-naphthyridine alkaloids lophocladine a and B

Arch Pharm (Weinheim). 2006 Dec;339(12):677-9. doi: 10.1002/ardp.200600134.

Authors

Matthias Lotter¹, Johannes Schilling, Eberhard Reimann, Franz Bracher

Affiliation

¹ Department Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, 81377 Munich, Germany.

PMID: 17109463
DOI: 10.1002/ardp.200600134

Abstract

The one-pot reaction of 4-benzylpyridine-3-carbonitrile with Bredereck's reagent and subsequent treatment with either glacial acetic acid and sulfuric acid or ammonium acetate provided the new bioactive naphthyridine alkaloids lophocladine A and B, respectively.

MeSH terms

Antineoplastic Agents, Phytogenic / chemical synthesis*
Antineoplastic Agents, Phytogenic / pharmacology
Chromatography, High Pressure Liquid
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Naphthyridines / chemical synthesis*
Naphthyridines / pharmacology
Spectroscopy, Fourier Transform Infrared
Stereoisomerism

Substances

Antineoplastic Agents, Phytogenic
Indicators and Reagents
Naphthyridines
lophocladine A
lophocladine B