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Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
Humphreys PG, Anderson NA, Bamborough P, Baxter A, Chung CW, Cookson R, Craggs PD, Dalton T, Fournier JCL, Gordon LJ, Gray HF, Gray MW, Gregory R, Hirst DJ, Jamieson C, Jones KL, Kessedjian H, Lugo D, McGonagle G, Patel VK, Patten C, Poole DL, Prinjha RK, Ramirez-Molina C, Rioja I, Seal G, Stafford KAJ, Shah RR, Tape D, Theodoulou NH, Tomlinson L, Ukuser S, Wall ID, Wellaway N, White G. Humphreys PG, et al. Among authors: gray mw. J Med Chem. 2022 Nov 24;65(22):15174-15207. doi: 10.1021/acs.jmedchem.2c01102. Epub 2022 Nov 15. J Med Chem. 2022. PMID: 36378954
Ocean Acidification Has Multiple Modes of Action on Bivalve Larvae.
Waldbusser GG, Hales B, Langdon CJ, Haley BA, Schrader P, Brunner EL, Gray MW, Miller CA, Gimenez I, Hutchinson G. Waldbusser GG, et al. Among authors: gray mw. PLoS One. 2015 Jun 10;10(6):e0128376. doi: 10.1371/journal.pone.0128376. eCollection 2015. PLoS One. 2015. PMID: 26061095 Free PMC article.