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Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.
Tomás CC, Oliveira E, Sousa D, Uba-Chupel M, Furtado G, Rocha C, Teixeira A, Ferreira P, Alves C, Gisin S, Catarino E, Carvalho N, Coucelo T, Bonfim L, Silva C, Franco D, González JA, Jardim HG, Silva R, Baixinho CL, Presado MªH, Marques MªF, Cardoso ME, Cunha M, Mendes J, Xavier A, Galhardo A, Couto M, Frade JG, Nunes C, Mesquita JR, Nascimento MS, Gonçalves G, Castro C, Mártires A, Monteiro MªJ, Rainho C, Caballero FP, Monago FM, Guerrero JT, Monago RM, Trigo AP, Gutierrez ML, Milanés GM, Reina MG, Villanueva AG, Piñero AS, Aliseda IR, Ramirez FB, Ribeiro A, Quelhas A, Manso C, Caballero FP, Guerrero JT, Monago FM, Santos RB, Jimenez NR, Nuñez CG, Gomez IR, Fernandez MªJL, Marquez LA, Moreno AL, Huertas MªJT, Ramirez FB, Seabra D, Salvador MªC, Braga L, Parreira P, Salgueiro-Oliveira A, Arreguy-Sena C, Oliveira BF, Henriques MªA, Santos J, Lebre S, Marques A, Festas C, Rodrigues S, Ribeiro A, Lumini J, Figueiredo AG, Hernandez-Martinez FJ, Campi L, Quintana-Montesdeoca MªP, Jimenez-Diaz JF, Rodriguez-De-Vera BC, Parente A, Mata MªA, Pereira AMª, Fernandes A, Brás M, Pinto MªR, Parreira P, Basto ML, Rei AC, Mónico LM, Sousa G, Morna C, Freitas O, Freitas G, Jardim A, Vasconcelos … See abstract for full author list ➔ Tomás CC, et al. BMC Health Serv Res. 2016 Jul 6;16 Suppl 3(Suppl 3):200. doi: 10.1186/s12913-016-1423-5. BMC Health Serv Res. 2016. PMID: 27409075 Free PMC article.
Oliveira, Luisa S. Brito, Italo N. Pinto, Alessandra S. Furtado, Regia B. Castro, Caroline Q. Aquino, Eveliny S. Martins O179 Women's beliefs about pap smear test and cervical cancer: influence of social determinants Ana B Pinheiro, Priscila S. …
Oliveira, Luisa S. Brito, Italo N. Pinto, Alessandra S. Furtado, Regia B. Castro, Caroline Q. Aquino, Eveliny S. Martin …
Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life.
Santos-García D, de Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Íñiguez-Alvarado MC, García Díaz I, Jesús S, Buongiorno MT, Planellas L, Cosgaya M, García Caldentey J, Caballol N, Legarda I, Hernández Vara J, Cabo I, López Manzanares L, González Aramburu I, Ávila Rivera MA, Gómez Mayordomo V, Nogueira V, Puente V, Dotor García-Soto J, Borrué C, Solano Vila B, Álvarez Sauco M, Vela L, Escalante S, Cubo E, Carrillo Padilla F, Martínez Castrillo JC, Sánchez Alonso P, Alonso Losada MG, López Ariztegui N, Gastón I, Kulisevsky J, Menéndez González M, Seijo M, Ruiz Martínez J, Valero C, Kurtis M, González Ardura J, Alonso Redondo R, Ordás C, López Díaz LM, McAfee D, Calopa M, Carrillo F, Escamilla Sevilla F, Freire-Alvarez E, Gómez Esteban JC, García Ramos R, Luquín MRI, Martínez-Torres I, Sesar Ignacio Á, Martinez-Martin P, Mir P; COPPADIS Study Group. Santos-García D, et al. J Parkinsons Dis. 2023;13(3):379-402. doi: 10.3233/JPD-225073. J Parkinsons Dis. 2023. PMID: 36911948 Free PMC article.
BACKGROUND: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). OBJECTIVE: Our aim was to apply the MNCD classification in a cohort of PD patien …
BACKGROUND: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has …
The mechanisms underlying montelukast's neuropsychiatric effects - new insights from a combined metabolic and multiomics approach.
Marques CF, Marques MM, Justino GC. Marques CF, et al. Life Sci. 2022 Dec 1;310:121056. doi: 10.1016/j.lfs.2022.121056. Epub 2022 Oct 10. Life Sci. 2022. PMID: 36228771 Free article.
KEY FINDINGS: Eighteen new MTK metabolites were identified. MTK's ability to react with glutathione was confirmed. The multi-omics approach employed confirmed that montelukast interferes with the glutathione detoxification system in the brain. ...
KEY FINDINGS: Eighteen new MTK metabolites were identified. MTK's ability to react with glutathione was confirmed. The multi-omics ap …
Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors.
Mahgoub MY, Elmaghraby AM, Harb AA, Ferreira da Silva JL, Justino GC, Marques MM. Mahgoub MY, et al. Molecules. 2019 Jun 21;24(12):2306. doi: 10.3390/molecules24122306. Molecules. 2019. PMID: 31234400 Free PMC article.
These results provide a promising and new starting point to improve acetylcholinesterase inhibitors and explore novel treatment options against Alzheimer's disease....
These results provide a promising and new starting point to improve acetylcholinesterase inhibitors and explore novel treatment options agai …
The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.
Matilde Marques M, Gamboa da Costa G, Blankenship LR, Culp SJ, Beland FA. Matilde Marques M, et al. Mutat Res. 2002 Sep 30;506-507:41-8. doi: 10.1016/s0027-5107(02)00150-1. Mutat Res. 2002. PMID: 12351143
With N-hydroxy-4-fluoro-2,6-DMA, the mutant frequency was reduced by approximately 90% in S. typhimurium TA100 and approximately 50% in S. typhimurium TA98. The results suggest that multiple adducts contribute to base substitution mutations detected by S. typ …
With N-hydroxy-4-fluoro-2,6-DMA, the mutant frequency was reduced by approximately 90% in S. typhimurium TA100 and approximately 50% …
The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Fremy's salt.
Harjivan SG, Wanke R, Ferreira da Silva JL, Marques MM, Antunes AM. Harjivan SG, et al. Eur J Med Chem. 2014 Mar 3;74:7-11. doi: 10.1016/j.ejmech.2013.12.022. Epub 2013 Dec 31. Eur J Med Chem. 2014. PMID: 24440376
We investigated the in vitro oxidation of the phenolic EFV metabolites, 7-hydroxy-efavirenz (7-OH-EFV) and 8-hydroxy-efavirenz (8-OH-EFV), with Fremy's salt. A quinoline derivative, 6-chloro-2-cyclopropyl-4-(trifluoromethyl)quinolin-7-ol, presumably stemming from a radical …
We investigated the in vitro oxidation of the phenolic EFV metabolites, 7-hydroxy-efavirenz (7-OH-EFV) and 8-hydroxy-efavirenz (8-OH-EFV), w …