Biological aging of CNS-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease.
Atkinson JR, Jerome AD, Sas AR, Munie A, Wang C, Ma A, Arnold WD, Segal BM.
Atkinson JR, et al.
JCI Insight. 2022 Jun 22;7(12):e158153. doi: 10.1172/jci.insight.158153.
JCI Insight. 2022.
PMID: 35511417
Free PMC article.
Here, we show that experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of encephalitogenic CD4+ Th17 cells, was more severe, and less likely to remit, in middle-aged compared with young adult mice. Donor T cells and neutrophils were more abund …
Here, we show that experimental autoimmune encephalomyelitis (EAE), induced by the adoptive transfer of encephalitogenic CD4+ Th17 cells, wa …