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Differentiation agents increase the potential AraC therapy of AML by reactivating cell death pathways without enhancing ROS generation.
J Cell Physiol. 2020 Jan;235(1):573-586. doi: 10.1002/jcp.28996. Epub 2019 Jun 27.
J Cell Physiol. 2020.
PMID: 31245853
Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.
Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M.
Nachliely M, et al.
J Steroid Biochem Mol Biol. 2019 Apr;188:8-16. doi: 10.1016/j.jsbmb.2018.11.017. Epub 2018 Nov 30.
J Steroid Biochem Mol Biol. 2019.
PMID: 30508646
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Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells.
Nachliely M, Sharony E, Bolla NR, Kutner A, Danilenko M.
Nachliely M, et al.
Int J Mol Sci. 2016 Jul 5;17(7):1068. doi: 10.3390/ijms17071068.
Int J Mol Sci. 2016.
PMID: 27399677
Free PMC article.
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Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.
Pesakhov S, Nachliely M, Barvish Z, Aqaqe N, Schwartzman B, Voronov E, Sharoni Y, Studzinski GP, Fishman D, Danilenko M.
Pesakhov S, et al. Among authors: nachliely m.
Oncotarget. 2016 May 31;7(22):31847-61. doi: 10.18632/oncotarget.7240.
Oncotarget. 2016.
PMID: 26870993
Free PMC article.
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Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.
Nachliely M, Sharony E, Kutner A, Danilenko M.
Nachliely M, et al.
J Steroid Biochem Mol Biol. 2016 Nov;164:59-65. doi: 10.1016/j.jsbmb.2015.09.014. Epub 2015 Sep 10.
J Steroid Biochem Mol Biol. 2016.
PMID: 26365556
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