Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO

Kazuko Yoshikawa; Kazuaki Koso; Masumi Shimomura; Masami Tanaka; Hirofumi Yamamoto; Hiroshi Imagawa; Shigenobu Arihara; Toshihiro Hashimoto

doi:10.3390/molecules18044181

Yellow pigments, fomitellanols A and B, and drimane sesquiterpenoids, cryptoporic acids P and Q, from Fomitella fraxinea and their inhibitory activity against COX and 5-LO

Molecules. 2013 Apr 9;18(4):4181-91. doi: 10.3390/molecules18044181.

Authors

Kazuko Yoshikawa¹, Kazuaki Koso, Masumi Shimomura, Masami Tanaka, Hirofumi Yamamoto, Hiroshi Imagawa, Shigenobu Arihara, Toshihiro Hashimoto

Affiliation

¹ Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan. yosikawa@ph.bunri-u.ac.jp

Abstract

Yellow pigments, fomitellanols A (1a) and B (2a), and drimane-type sesquiterpenoid ethers of isocitric acid, cryptoporic acids P (3) and Q (4), have been isolated from the fruiting bodies of Fomitella fraxinea (Polyporaceae). Their structures were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analyses, and their biological activity against COX-1, COX-2, and 5-LO was investigated.

MeSH terms

Crystallography, X-Ray
Cyclooxygenase Inhibitors / chemistry
Cyclooxygenase Inhibitors / pharmacology*
Lipoxygenase Inhibitors / chemistry
Lipoxygenase Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Polycyclic Sesquiterpenes
Polyporaceae / metabolism*
Sesquiterpenes / chemistry
Sesquiterpenes / pharmacology*

Substances

Cyclooxygenase Inhibitors
Lipoxygenase Inhibitors
Polycyclic Sesquiterpenes
Sesquiterpenes
drimane
fomitellanol A
fomitellanol B