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Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer.
Bedard MC, Chihanga T, Carlile A, Jackson R, Brusadelli MG, Lee D, VonHandorf A, Rochman M, Dexheimer PJ, Chalmers J, Nuovo G, Lehn M, Williams DEJ, Kulkarni A, Carey M, Jackson A, Billingsley C, Tang A, Zender C, Patil Y, Wise-Draper TM, Herzog TJ, Ferris RL, Kendler A, Aronow BJ, Kofron M, Rothenberg ME, Weirauch MT, Van Doorslaer K, Wikenheiser-Brokamp KA, Lambert PF, Adam M, Steven Potter S, Wells SI. Bedard MC, et al. Nat Commun. 2023 Apr 8;14(1):1975. doi: 10.1038/s41467-023-37377-0. Nat Commun. 2023. PMID: 37031202 Free PMC article.
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.
Ruiz-Torres S, Brusadelli MG, Witte DP, Wikenheiser-Brokamp KA, Sauter S, Nelson AS, Sertorio M, Chlon TM, Lane A, Mehta PA, Myers KC, Bedard MC, Pal B, Supp DM, Lambert PF, Komurov K, Kovacic MB, Davies SM, Wells SI. Ruiz-Torres S, et al. Among authors: bedard mc. Cell Stem Cell. 2021 Mar 4;28(3):424-435.e6. doi: 10.1016/j.stem.2020.10.012. Epub 2020 Nov 23. Cell Stem Cell. 2021. PMID: 33232662 Free PMC article.
The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses.
Azouz NP, Ynga-Durand MA, Caldwell JM, Jain A, Rochman M, Fischesser DM, Ray LM, Bedard MC, Mingler MK, Forney C, Eilerman M, Kuhl JT, He H, Biagini Myers JM, Mukkada VA, Putnam PE, Khurana Hershey GK, Kottyan LC, Wen T, Martin LJ, Rothenberg ME. Azouz NP, et al. Among authors: bedard mc. Sci Transl Med. 2018 Jun 6;10(444):eaap9736. doi: 10.1126/scitranslmed.aap9736. Sci Transl Med. 2018. PMID: 29875205 Free PMC article.
Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis.
Rochman M, Travers J, Miracle CE, Bedard MC, Wen T, Azouz NP, Caldwell JM, Kc K, Sherrill JD, Davis BP, Rymer JK, Kaufman KM, Aronow BJ, Rothenberg ME. Rochman M, et al. Among authors: bedard mc. J Allergy Clin Immunol. 2017 Sep;140(3):738-749.e3. doi: 10.1016/j.jaci.2016.11.042. Epub 2017 Jan 17. J Allergy Clin Immunol. 2017. PMID: 28104354 Free PMC article.