Synthesis of annulated pyridines as inhibitors of aldosterone synthase (CYP11B2).
Org Biomol Chem. 2016 Jul 7;14(25):5922-7. doi: 10.1039/c6ob00848h. Epub 2016 Jun 1.
Org Biomol Chem. 2016.
PMID: 27245438
A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat'eva reactions. Preparation of the analogous cyclohexa[c]pyridines led to the identification of a potent and more selective AS inhibitor. …
A series of cyclopenta[c]pyridine aldosterone synthase (AS) inhibitors were conveniently accessed using batch or continuous flow Kondrat …