Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

Martin Schoeller; Milan Piroš; Miroslava Litecká; Katarína Koňariková; Flóra Jozefíková; Alexandra Šagátová; Eva Zahradníková; Jindra Valentová; Ján Moncol

doi:10.3390/molecules28124609

Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

Molecules. 2023 Jun 7;28(12):4609. doi: 10.3390/molecules28124609.

Authors

Martin Schoeller¹, Milan Piroš¹, Miroslava Litecká², Katarína Koňariková³, Flóra Jozefíková^{1

4}, Alexandra Šagátová¹, Eva Zahradníková⁵, Jindra Valentová⁴, Ján Moncol¹

Affiliations

¹ Department of Inorganic Chemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
² Department of Materials Chemistry, Institute of Inorganic Chemistry of the CAS, Husinec-Řež č.p. 1001, 250 68 Řež, Czech Republic.
³ Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia.
⁴ Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, 832 32 Bratislava, Slovakia.
⁵ Department of Inorganic Chemistry, Faculty of Science, Palacký University, 17. Listopadu 12, 771 46 Olomouc, Czech Republic.

Abstract

Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2'-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods-FTIR, UV-Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.

Keywords: BSA; DNA; NSAID; Ruthenium(II); anticancer drugs; antiproliferative activity; crystal structure; medicinal inorganic chemistry; salicylate.

MeSH terms

Antineoplastic Agents* / chemistry
Cell Line, Tumor
Coordination Complexes* / chemistry
Halogens
Heterocyclic Compounds*
Protein Binding
Ruthenium* / chemistry
Ruthenium* / pharmacology

Substances

Ruthenium
Halogens
Heterocyclic Compounds
Coordination Complexes
Antineoplastic Agents

Abstract

MeSH terms

Substances

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