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De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569. doi: 10.1073/pnas.1902766117. Epub 2020 Jan 21.
Proc Natl Acad Sci U S A. 2020.
PMID: 31964835
Free PMC article.
EHD2 restrains dynamics of caveolae by an ATP-dependent, membrane-bound, open conformation.
Hoernke M, Mohan J, Larsson E, Blomberg J, Kahra D, Westenhoff S, Schwieger C, Lundmark R.
Hoernke M, et al.
Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4360-E4369. doi: 10.1073/pnas.1614066114. Epub 2017 Feb 21.
Proc Natl Acad Sci U S A. 2017.
PMID: 28223496
Free PMC article.
It is still unclear how ATP is used in this process and whether membrane binding is coupled to conformational changes in the protein. Here, we show that the regulatory N-terminal residues and the EH domain keep the EHD2 dimer in an autoinhibited conformation in solution. . …
It is still unclear how ATP is used in this process and whether membrane binding is coupled to conformational changes in the protein. Here, …
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