Chronic diseases are increasing problem of public health in the world. In countries such as Colombia these diseases are an important cause of morbidity and mortality. Taking into account this situation several organizations have recommended planning and conducting actions to prevent chronic diseases, however there are scarce initiatives addressed to this purpose which reflect a reality that has been named as the "neglected epidemic of chronic diseases". This article describes the experience of formulation of a local plan for the prevention of chronic diseases in the Colombian city of Pasto where was used a planning model developed by the World Health Organization. The goal of this plan is reduce in the following ten year the prevalence of the three main risk factors for chronic disease between 5 to 10% addressing the actions in public policies, contexts for the daily life, health services and the generation of evidence to make decisions through an observatory in chronic diseases. This experience showed up the importance and feasibility of this process at the local context and identified the coordination with the national level as one of the main challenges to be considered to carry out these initiatives.