Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

bioRxiv [Preprint]. 2023 Dec 14:2023.11.28.569095. doi: 10.1101/2023.11.28.569095.

Abstract

This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.

Keywords: 3D reconstruction; MICOS complex; Mitochondria; heart failure; myofibril.

Publication types

  • Preprint