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Page 1
T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production.
van Asten SD, de Groot R, van Loenen MM, Castenmiller SM, de Jong J, Monkhorst K, Haanen JBAG, Amsen D, Bex A, Spaapen RM, Wolkers MC. van Asten SD, et al. Among authors: van loenen mm. Oncoimmunology. 2021 Jan 21;10(1):1860482. doi: 10.1080/2162402X.2020.1860482. Oncoimmunology. 2021. PMID: 33537169 Free PMC article.
Allo-HLA reactivity of virus-specific memory T cells is common.
Amir AL, D'Orsogna LJ, Roelen DL, van Loenen MM, Hagedoorn RS, de Boer R, van der Hoorn MA, Kester MG, Doxiadis II, Falkenburg JH, Claas FH, Heemskerk MH. Amir AL, et al. Among authors: van loenen mm. Blood. 2010 Apr 15;115(15):3146-57. doi: 10.1182/blood-2009-07-234906. Epub 2010 Feb 16. Blood. 2010. PMID: 20160165 Free article.
Mixed T cell receptor dimers harbor potentially harmful neoreactivity.
van Loenen MM, de Boer R, Amir AL, Hagedoorn RS, Volbeda GL, Willemze R, van Rood JJ, Falkenburg JH, Heemskerk MH. van Loenen MM, et al. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10972-7. doi: 10.1073/pnas.1005802107. Epub 2010 Jun 1. Proc Natl Acad Sci U S A. 2010. PMID: 20534461 Free PMC article.
HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study.
van Balen P, Jedema I, van Loenen MM, de Boer R, van Egmond HM, Hagedoorn RS, Hoogstaten C, Veld SAJ, Hageman L, van Liempt PAG, Zwaginga JJ, Meij P, Veelken H, Falkenburg JHF, Heemskerk MHM. van Balen P, et al. Among authors: van loenen mm. Front Immunol. 2020 Aug 20;11:1804. doi: 10.3389/fimmu.2020.01804. eCollection 2020. Front Immunol. 2020. PMID: 32973756 Free PMC article. Clinical Trial.
Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile.
De Groot R, Van Loenen MM, Guislain A, Nicolet BP, Freen-Van Heeren JJ, Verhagen OJHM, Van Den Heuvel MM, De Jong J, Burger P, Van Der Schoot CE, Spaapen RM, Amsen D, Haanen JBAG, Monkhorst K, Hartemink KJ, Wolkers MC. De Groot R, et al. Among authors: van loenen mm. Oncoimmunology. 2019 Aug 15;8(11):e1648170. doi: 10.1080/2162402X.2019.1648170. eCollection 2019. Oncoimmunology. 2019. PMID: 31646094 Free PMC article.
15 results