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RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals.
Lesch M, Luckner M, Meyer M, Weege F, Gravenstein I, Raftery M, Sieben C, Martin-Sancho L, Imai-Matsushima A, Welke RW, Frise R, Barclay W, Schönrich G, Herrmann A, Meyer TF, Karlas A. Lesch M, et al. PLoS Pathog. 2019 Mar 18;15(3):e1007601. doi: 10.1371/journal.ppat.1007601. eCollection 2019 Mar. PLoS Pathog. 2019. PMID: 30883607 Free PMC article.
Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells.
Wörmann X, Lesch M, Welke RW, Okonechnikov K, Abdurishid M, Sieben C, Geissner A, Brinkmann V, Kastner M, Karner A, Zhu R, Hinterdorfer P, Anish C, Seeberger PH, Herrmann A, Meyer TF, Karlas A. Wörmann X, et al. Among authors: lesch m. Virology. 2016 May;492:118-29. doi: 10.1016/j.virol.2016.02.002. Epub 2016 Feb 23. Virology. 2016. PMID: 26914510 Free article.
Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells.
Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T. Sadewasser A, et al. Among authors: lesch m. Mol Cell Proteomics. 2017 May;16(5):728-742. doi: 10.1074/mcp.M116.065904. Epub 2017 Mar 13. Mol Cell Proteomics. 2017. PMID: 28289176 Free PMC article.