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Transgenic Mouse Models of Alzheimer's Disease: An Integrative Analysis.
Sanchez-Varo R, Mejias-Ortega M, Fernandez-Valenzuela JJ, Nuñez-Diaz C, Caceres-Palomo L, Vegas-Gomez L, Sanchez-Mejias E, Trujillo-Estrada L, Garcia-Leon JA, Moreno-Gonzalez I, Vizuete M, Vitorica J, Baglietto-Vargas D, Gutierrez A. Sanchez-Varo R, et al. Among authors: mejias ortega m. Int J Mol Sci. 2022 May 12;23(10):5404. doi: 10.3390/ijms23105404. Int J Mol Sci. 2022. PMID: 35628216 Free PMC article. Review.
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer's disease hippocampus.
Muñoz-Castro C, Mejias-Ortega M, Sanchez-Mejias E, Navarro V, Trujillo-Estrada L, Jimenez S, Garcia-Leon JA, Fernandez-Valenzuela JJ, Sanchez-Mico MV, Romero-Molina C, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Gutierrez A, Vitorica J. Muñoz-Castro C, et al. Among authors: mejias ortega m. Acta Neuropathol Commun. 2023 Feb 28;11(1):31. doi: 10.1186/s40478-023-01530-z. Acta Neuropathol Commun. 2023. PMID: 36855152 Free PMC article.
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.
Kilian JG, Mejias-Ortega M, Hsu HW, Herman DA, Vidal J, Arechavala RJ, Renusch S, Dalal H, Hasen I, Ting A, Rodriguez-Ortiz CJ, Lim SL, Lin X, Vu J, Saito T, Saido TC, Kleinman MT, Kitazawa M. Kilian JG, et al. Among authors: mejias ortega m. Toxicol Sci. 2023 May 31;193(2):175-191. doi: 10.1093/toxsci/kfad036. Toxicol Sci. 2023. PMID: 37074955 Free PMC article.
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease.
Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Garcia-Leon JA, et al. Among authors: mejias ortega m. Int J Mol Sci. 2020 Sep 18;21(18):6867. doi: 10.3390/ijms21186867. Int J Mol Sci. 2020. PMID: 32962164 Free PMC article. Review.
An Insertion Within SIRPβ1 Shows a Dual Effect Over Alzheimer's Disease Cognitive Decline Altering the Microglial Response.
García-Alberca JM, de Rojas I, Sanchez-Mejias E, Garrido-Martín D, Gonzalez-Palma L, Jimenez S, Pino-Angeles A, Cruz-Gamero JM, Mendoza S, Alarcón-Martín E; GERALD consortium; Muñoz-Castro C, Real LM, Tena JJ, Polvillo R, Govantes F, Lopez A, Royo-Aguado JL, Navarro V, Gonzalez I, Ruiz M, Reyes-Engel A, Gris E, Bravo MJ, Lopez-Gutierrez L, Mejias-Ortega M, De la Guía P, López de la Rica M, Ocejo O, Torrecilla J, Zafra C, Nieto MD, Urbano C, Jiménez-Sánchez R, Pareja N, Luque M, García-Peralta M, Carrillejo R, Furniet MDC, Rueda L, Sánchez-Fernández A, Mancilla T, Peña I, García-Casares N, Moreno-Grau S, Hernández I, Montrreal L, Quintela I, González-Pérez A, Calero M, Franco-Macías E, Macías J, Menéndez-González M, Frank-García A, Huerto Vilas R, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Valero S, Sotolongo-Grau O, Pérez-Cordón A, Rábano A, Arias Pastor A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes Á, Sanabria Á, Martínez Rodríguez C, Buiza-Rueda D, Rodriguez-Rodriguez E, Ortega G, Alvarez I, Rosas Allende I, Pineda JA, Rosende-Roca M, Bernal Sánchez-Arjona M, Fernández-Fuertes M, Alegret M, Roberto N, Del Ser T, Garcia-Ribas G, Sánchez-Juan P, Pa… See abstract for full author list ➔ García-Alberca JM, et al. Among authors: mejias ortega m. J Alzheimers Dis. 2024;98(2):601-618. doi: 10.3233/JAD-231150. J Alzheimers Dis. 2024. PMID: 38427484
Angiotensin receptor blockade with olmesartan alleviates brain pathology in obese OLETF rats.
Rodriguez-Ortiz CJ, Thorwald MA, Rodriguez R, Mejias-Ortega M, Kieu Z, Maitra N, Hawkins C, Valenzuela J, Peng M, Nishiyama A, Ortiz RM, Kitazawa M. Rodriguez-Ortiz CJ, et al. Among authors: mejias ortega m. Clin Exp Pharmacol Physiol. 2023 Mar;50(3):228-237. doi: 10.1111/1440-1681.13738. Epub 2022 Dec 4. Clin Exp Pharmacol Physiol. 2023. PMID: 36398458 Free PMC article.
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients.
Sanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A. Sanchez-Mejias E, et al. Among authors: mejias ortega m. Brain Pathol. 2020 Mar;30(2):345-363. doi: 10.1111/bpa.12785. Epub 2019 Oct 9. Brain Pathol. 2020. PMID: 31491047 Free PMC article.
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.
Sanchez-Varo R, Sanchez-Mejias E, Fernandez-Valenzuela JJ, De Castro V, Mejias-Ortega M, Gomez-Arboledas A, Jimenez S, Sanchez-Mico MV, Trujillo-Estrada L, Moreno-Gonzalez I, Baglietto-Vargas D, Vizuete M, Davila JC, Vitorica J, Gutierrez A. Sanchez-Varo R, et al. Among authors: mejias ortega m. Front Neurosci. 2021 Nov 4;15:752594. doi: 10.3389/fnins.2021.752594. eCollection 2021. Front Neurosci. 2021. PMID: 34803589 Free PMC article.