In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury.
Federti E, Matte A, Recchiuti A, Garello F, Ghigo A, El Nemer W, Terreno E, Amoresano A, Mattoscio D, Turrini F, Lebouef C, Janin A, Pantaleo A, Russo R, Marin M, Iatcencko I, Riccardi V, Siciliano A, Iolascon A, Brugnara C, De Franceschi L.
Federti E, et al.
Hemasphere. 2023 Feb 28;7(3):e848. doi: 10.1097/HS9.0000000000000848. eCollection 2023 Mar.
Hemasphere. 2023.
PMID: 36874380
Free PMC article.
In addition, imatinib inhibits the platelet-derived growth factor-B-dependent pathway, interfering with the profibrotic response to hypoxia/reperfusion injury, used to mimic acute VOCs. Our data indicate that imatinib might be considered as possible new therapeutic tool fo …
In addition, imatinib inhibits the platelet-derived growth factor-B-dependent pathway, interfering with the profibrotic response to hypoxia/ …