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Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer.
Busenhart P, Montalban-Arques A, Katkeviciute E, Morsy Y, Van Passen C, Hering L, Atrott K, Lang S, Garzon JFG, Naschberger E, Hartmann A, Rogler G, Stürzl M, Spalinger MR, Scharl M. Busenhart P, et al. Among authors: spalinger mr. J Immunother Cancer. 2022 Feb;10(2):e003465. doi: 10.1136/jitc-2021-003465. J Immunother Cancer. 2022. PMID: 35131862 Free PMC article.
Co-cultivation is a powerful approach to produce a robust functionally designed synthetic consortium as a live biotherapeutic product (LBP).
Kurt F, Leventhal GE, Spalinger MR, Anthamatten L, Rogalla von Bieberstein P, Menzi C, Reichlin M, Meola M, Rosenthal F, Rogler G, Lacroix C, de Wouters T. Kurt F, et al. Among authors: spalinger mr. Gut Microbes. 2023 Jan-Dec;15(1):2177486. doi: 10.1080/19490976.2023.2177486. Gut Microbes. 2023. PMID: 36794804 Free PMC article.