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A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R. Sebastian C, et al. Among authors: vara messler m. Nat Commun. 2022 Mar 21;13(1):1503. doi: 10.1038/s41467-022-29085-y. Nat Commun. 2022. PMID: 35314684 Free PMC article.
A potential role of PUFAs and COXIBs in cancer chemoprevention.
Vara-Messler M, Buccellati C, Pustina L, Folco G, Rovati GE, Hoxha M. Vara-Messler M, et al. Prostaglandins Other Lipid Mediat. 2015 Jul;120:97-102. doi: 10.1016/j.prostaglandins.2015.04.003. Epub 2015 Apr 20. Prostaglandins Other Lipid Mediat. 2015. PMID: 25908304 Review.
Metabolic adaptation towards glycolysis supports resistance to neoadjuvant chemotherapy in early triple negative breast cancers.
Derouane F, Desgres M, Moroni C, Ambroise J, Berlière M, Van Bockstal MR, Galant C, van Marcke C, Vara-Messler M, Hutten SJ, Jonkers J, Mourao L, Scheele CLGJ, Duhoux FP, Corbet C. Derouane F, et al. Among authors: vara messler m. Breast Cancer Res. 2024 Feb 19;26(1):29. doi: 10.1186/s13058-024-01788-8. Breast Cancer Res. 2024. PMID: 38374113 Free PMC article.
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.
Comba A, Almada LL, Tolosa EJ, Iguchi E, Marks DL, Vara Messler M, Silva R, Fernandez-Barrena MG, Enriquez-Hesles E, Vrabel AL, Botta B, Di Marcotulio L, Ellenrieder V, Eynard AR, Pasqualini ME, Fernandez-Zapico ME. Comba A, et al. Among authors: vara messler m. J Biol Chem. 2016 Jan 22;291(4):1933-1947. doi: 10.1074/jbc.M115.691972. Epub 2015 Nov 24. J Biol Chem. 2016. PMID: 26601952 Free PMC article.