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Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial.
Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, Abad J, Duran-Cantolla J, Cabriada V, Mediano O, Masdeu MJ, Alonso ML, Masa JF, Barceló A, de la Peña M, Mayos M, Coloma R, Montserrat JM, Chiner E, Perelló S, Rubinós G, Mínguez O, Pascual L, Cortijo A, Martínez D, Aldomà A, Dalmases M, McEvoy RD, Barbé F; Spanish Sleep Network. Sánchez-de-la-Torre M, et al. Lancet Respir Med. 2020 Apr;8(4):359-367. doi: 10.1016/S2213-2600(19)30271-1. Epub 2019 Dec 12. Lancet Respir Med. 2020. PMID: 31839558 Clinical Trial.
The prevalence of cardiovascular events was similar in the CPAP and UC groups (98 events [16%] vs 108 events [17%]; hazard ratio [HR] 0.89 [95% CI 0.68-1.17]; p=0.40) during follow-up. Mean time of adherence to CPAP treatment was 2.78 h/night (SD 2.73). The prevalence of c …
The prevalence of cardiovascular events was similar in the CPAP and UC groups (98 events [16%] vs 108 events [17%]; hazard ratio [HR] 0.89 [ …
Beyond Resistant Hypertension.
Martínez-García MA, Navarro-Soriano C, Torres G, Barbé F, Caballero-Eraso C, Lloberes P, Diaz-Cambriles T, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Selma-Ferrer MJ, García Ortega A, Campos-Rodriguez F; on behalf the Spanish Sleep Network. Martínez-García MA, et al. Hypertension. 2018 Sep;72(3):618-624. doi: 10.1161/HYPERTENSIONAHA.118.11170. Hypertension. 2018. PMID: 30354751 Free article.
Compared with those with RH, patients with RfH had a higher cardiovascular risk profile, higher blood pressure measurements, and a 2-fold greater risk of having both severe OSA (odds ratio, 2.1, with a prevalence of apnea-hypopnea index 15, 95.2% and apnea-hypopnea index 30, 64.3 …
Compared with those with RH, patients with RfH had a higher cardiovascular risk profile, higher blood pressure measurements, and a 2-fold gr …
Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts.
Agarwal A, Johnston BC, Vernooij RW, Carrasco-Labra A, Brignardello-Petersen R, Neumann I, Akl EA, Sun X, Briel M, Busse JW, Ebrahim S, Granados CE, Iorio A, Irfan A, Martínez García L, Mustafa RA, Ramirez-Morera A, Selva A, Solà I, Sanabrai AJ, Tikkinen KA, Vandvik PO, Zhang Y, Zazueta OE, Zhou Q, Schunemann HJ, Guyatt GH, Alonso-Coello P. Agarwal A, et al. J Clin Epidemiol. 2017 Jan;81:3-12. doi: 10.1016/j.jclinepi.2016.08.004. Epub 2016 Aug 21. J Clin Epidemiol. 2017. PMID: 27555080 Review.
Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?
Servia-Goixart L, Lopez-Delgado JC, Grau-Carmona T, Trujillano-Cabello J, Bordeje-Laguna ML, Mor-Marco E, Portugal-Rodriguez E, Lorencio-Cardenas C, Montejo-Gonzalez JC, Vera-Artazcoz P, Macaya-Redin L, Martinez-Carmona JF, Iglesias-Rodriguez R, Monge-Donaire D, Flordelis-Lasierra JL, Llorente-Ruiz B, Menor-Fernández EM, Martínez de Lagrán I, Yebenes-Reyes JC; ENPIC Study Investigators. Servia-Goixart L, et al. Clin Nutr ESPEN. 2022 Feb;47:325-332. doi: 10.1016/j.clnesp.2021.11.018. Epub 2021 Nov 16. Clin Nutr ESPEN. 2022. PMID: 35063222 Free article.

Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6 3.3 vs 8.4 3.7; P < 0.001); greater nutritional risk (Nutrition Risk in the Critically Ill [NUTRIC]

…
Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure …
Systematic reviews experience major limitations in reporting absolute effects.
Alonso-Coello P, Carrasco-Labra A, Brignardello-Petersen R, Neumann I, Akl EA, Vernooij RW, Johnston BC, Sun X, Briel M, Busse JW, Ebrahim S, Granados CE, Iorio A, Irfan A, Martínez García L, Mustafa RA, Ramírez-Morera A, Selva A, Solà I, Sanabria AJ, Tikkinen KA, Vandvik PO, Zazueta OE, Zhang Y, Zhou Q, Schünemann H, Guyatt GH. Alonso-Coello P, et al. J Clin Epidemiol. 2016 Apr;72:16-26. doi: 10.1016/j.jclinepi.2015.11.002. Epub 2015 Nov 10. J Clin Epidemiol. 2016. PMID: 26560992
The HIPARCO-2 study: long-term effect of continuous positive airway pressure on blood pressure in patients with resistant hypertension: a multicenter prospective study.
Navarro-Soriano C, Torres G, Barbé F, Sánchez-de-la-Torre M, Mañas P, Lloberes P, Cambriles TD, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, García-Ortega A, Posadas T, Campos-Rodríguez F, Martínez-García MÁ; on behalf the Spanish Sleep Network. Navarro-Soriano C, et al. J Hypertens. 2021 Feb 1;39(2):302-309. doi: 10.1097/HJH.0000000000002664. J Hypertens. 2021. PMID: 33239552
Finally, there was a positive correlation between the drop in 24-h SBP and the hours of CPAP use (r = 0.24; P = 0.01). CONCLUSION: Good adherence to long-term CPAP treatment largely succeeded in significantly reducing BP in those patients with OSA and resistant hypertensio …
Finally, there was a positive correlation between the drop in 24-h SBP and the hours of CPAP use (r = 0.24; P = 0.01). CONCLUSION: Go …
Long-term Effect of CPAP Treatment on Cardiovascular Events in Patients With Resistant Hypertension and Sleep Apnea. Data From the HIPARCO-2 Study.
Navarro-Soriano C, Martínez-García MA, Torres G, Barbé F, Sánchez-de-la-Torre M, Caballero-Eraso C, Lloberes P, Cambriles TD, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, García-Ortega A, Posadas T, Campos-Rodríguez F; on behalf the Spanish Sleep Network. Navarro-Soriano C, et al. Arch Bronconeumol (Engl Ed). 2021 Mar;57(3):165-171. doi: 10.1016/j.arbres.2019.12.006. Epub 2020 Feb 3. Arch Bronconeumol (Engl Ed). 2021. PMID: 32029279 Free article. English, Spanish.
Patients not adherent to CPAP presented a non-significant increase in the total CVE incidence (HR:1.6; 95%CI: 0.96-2.7; p=0.07). A sensitivity analysis showed that patients not adherent to CPAP had a significant increase in the incidence of cerebrovascular events (HR: 3.1; …
Patients not adherent to CPAP presented a non-significant increase in the total CVE incidence (HR:1.6; 95%CI: 0.96-2.7; p=0.07). A se …
Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea.
Santamaria-Martos F, Benítez I, Girón C, Barbé F, Martínez-García MA, Hernández L, Montserrat JM, Nagore E, Martorell A, Campos-Rodriguez F, Corral J, Cabriada V, Abad J, Mediano O, Troncoso MF, Cano-Pumarega I, Fortuna Gutierrez AM, Diaz-Cambriles T, Somoza-Gonzalez M, Almendros I, Farre R, Gozal D, Sánchez-de-la-Torre M; Spanish Sleep Network. Santamaria-Martos F, et al. Eur Respir J. 2018 Mar 15;51(3):1701885. doi: 10.1183/13993003.01885-2017. Print 2018 Mar. Eur Respir J. 2018. PMID: 29519923 Free article.
The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that coul …
The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-sever …
Effect of continuous positive airway pressure in patients with true refractory hypertension and sleep apnea: a post-hoc intention-to-treat analysis of the HIPARCO randomized clinical trial.
Navarro-Soriano C, Martínez-García MA, Torres G, Barbé F, Caballero-Eraso C, Lloberes P, Diaz Cambriles T, Somoza M, Masa JF, González M, Mañas E, de la Peña M, García-Río F, Montserrat JM, Muriel A, Oscullo G, Feced Olmos L, García-Ortega A, Calhoun D, Campos-Rodriguez F; on behalf the Spanish Sleep Network. Navarro-Soriano C, et al. J Hypertens. 2019 Jun;37(6):1269-1275. doi: 10.1097/HJH.0000000000002053. J Hypertens. 2019. PMID: 30676482 Clinical Trial.
BP readings dropped more marked in patients with RfH than resistant hypertension, in both 24-h SBP (-9 vs. -1.6 mmHg, P = 0.021) and 24-h DBP (-7.3 vs. -2.3 mmHg, P = 0.074), especially at night (-11.3 vs. -3.8, P = 0.121 and -8.8 vs. -2.2, P = 0.054) …
BP readings dropped more marked in patients with RfH than resistant hypertension, in both 24-h SBP (-9 vs. -1.6 mmHg, P = 0.021) and …
Precision Medicine in Patients With Resistant Hypertension and Obstructive Sleep Apnea: Blood Pressure Response to Continuous Positive Airway Pressure Treatment.
Sánchez-de-la-Torre M, Khalyfa A, Sánchez-de-la-Torre A, Martinez-Alonso M, Martinez-García MÁ, Barceló A, Lloberes P, Campos-Rodriguez F, Capote F, Diaz-de-Atauri MJ, Somoza M, González M, Masa JF, Gozal D, Barbé F; Spanish Sleep Network. Sánchez-de-la-Torre M, et al. J Am Coll Cardiol. 2015 Sep 1;66(9):1023-32. doi: 10.1016/j.jacc.2015.06.1315. J Am Coll Cardiol. 2015. PMID: 26314530 Free article. Clinical Trial.

RESULTS: The OSA responder group exhibited blood pressure decreases exceeding the observed median (>4.5 mm Hg) after CPAP, which were not present in the nonresponder group (4.5 mm Hg) (p < 0.01). Three miRNAs provided a discriminatory predictive model for such a favo

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RESULTS: The OSA responder group exhibited blood pressure decreases exceeding the observed median (>4.5 mm Hg) after CPAP, which were not …