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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Demange P, Joly E, Marcoux J, Zanon PRA, Listunov D, Rullière P, Barthes C, Noirot C, Izquierdo JB, Rozié A, Pradines K, Hee R, de Brito MV, Marcellin M, Serre RF, Bouchez O, Burlet-Schiltz O, Oliveira MCF, Ballereau S, Bernardes-Génisson V, Maraval V, Calsou P, Hacker SM, Génisson Y, Chauvin R, Britton S. Demange P, et al. Among authors: oliveira mcf. Elife. 2022 May 10;11:e73913. doi: 10.7554/eLife.73913. Elife. 2022. PMID: 35535493 Free PMC article.
The Isoflavanoid (+)-PTC Regulates Cell-Cycle Progression and Mitotic Spindle Assembly in a Prostate Cancer Cell Line.
Moraes de Farias K, Rosa-Ribeiro R, Souza EE, Kobarg J, Banwell MG, de Brito Vieira Neto J, Leyenne Alves Sales S, Roberto Ribeiro Costa P, Cavalcante Dos Santos R, Vilaça Gaspar F, Gomes Barreto Junior A, da Conceição Ferreira Oliveira M, Odorico de Moraes M, Libardi M Furtado C, Carvalho HF, Pessoa C. Moraes de Farias K, et al. Among authors: da conceicao ferreira oliveira m. Chem Biodivers. 2022 May;19(5):e202200102. doi: 10.1002/cbdv.202200102. Epub 2022 Apr 29. Chem Biodivers. 2022. PMID: 35362194