Craniofacial Development Is Fine-Tuned by Sox2

Nikolaos Panagiotis Mandalos; Aikaterini Dimou; Maria Angeliki Gavala; Efstathia Lambraki; Eumorphia Remboutsika

doi:10.3390/genes14020380

Craniofacial Development Is Fine-Tuned by Sox2

Genes (Basel). 2023 Jan 31;14(2):380. doi: 10.3390/genes14020380.

Authors

Nikolaos Panagiotis Mandalos^{1

2}, Aikaterini Dimou^{1

3}, Maria Angeliki Gavala^{1

4}, Efstathia Lambraki^{1

5}, Eumorphia Remboutsika^{1

6}

Affiliations

¹ University Research Institute of Maternal and Child Health & Precision Medicine, School of Medicine, National and Kapoditrian University of Athens, 115 27 Athens, Greece.
² National Cancer Institute, Frederick, MD 21702, USA.
³ Center for Translational Medicine and the Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
⁴ National Technical University of Athens, 157 80 Athens, Greece.
⁵ Polytechnic School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
⁶ Thrivus Institute for Biomedical Science and Technology, Constellations Ave, Accra GT-336-4330, Ghana.

Abstract

The precise control of neural crest stem cell delamination, migration and differentiation ensures proper craniofacial and head development. Sox2 shapes the ontogeny of the cranial neural crest to ensure precision of the cell flow in the developing head. Here, we review how Sox2 orchestrates signals that control these complex developmental processes.

Keywords: Sox1; Sox14; Sox21; Sox3; SoxB genes; SoxB1; SoxB2; development; differentiation; embryonic stem cells; induced pluripotent stem cells; neural crest stem cells; neural progenitor cells; neural stem cells; neurogenesis; regeneration.

Publication types

Review

MeSH terms

Cell Differentiation
Humans
Neural Crest*
SOXB1 Transcription Factors*

Substances

SOX2 protein, human
SOXB1 Transcription Factors

Grants and funding

This research received no external funding.