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2017 1
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2020 2
2021 2
2022 4
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Page 1
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives.
Reader J, Opperman DFL, van der Watt ME, Theron A, Leshabane M, da Rocha S, Turner J, Garrabrant K, Piña I, Mills C, Woster PM, Birkholtz LM. Reader J, et al. Among authors: van der watt me. Chembiochem. 2022 Nov 4;23(21):e202200427. doi: 10.1002/cbic.202200427. Epub 2022 Oct 6. Chembiochem. 2022. PMID: 36106425 Free PMC article.
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Reader J, van der Watt ME, Taylor D, Le Manach C, Mittal N, Ottilie S, Theron A, Moyo P, Erlank E, Nardini L, Venter N, Lauterbach S, Bezuidenhout B, Horatscheck A, van Heerden A, Spillman NJ, Cowell AN, Connacher J, Opperman D, Orchard LM, Llinás M, Istvan ES, Goldberg DE, Boyle GA, Calvo D, Mancama D, Coetzer TL, Winzeler EA, Duffy J, Koekemoer LL, Basarab G, Chibale K, Birkholtz LM. Reader J, et al. Among authors: van der watt me. Nat Commun. 2021 Jan 11;12(1):269. doi: 10.1038/s41467-020-20629-8. Nat Commun. 2021. PMID: 33431834 Free PMC article.
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products.
Moyo P, Shamburger W, van der Watt ME, Reader J, de Sousa ACC, Egan TJ, Maharaj VJ, Bringmann G, Birkholtz LM. Moyo P, et al. Among authors: van der watt me. Int J Parasitol Drugs Drug Resist. 2020 Aug;13:51-58. doi: 10.1016/j.ijpddr.2020.05.003. Epub 2020 May 24. Int J Parasitol Drugs Drug Resist. 2020. PMID: 32505117 Free PMC article.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K. Brunschwig C, et al. Among authors: van der watt me. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29941635 Free PMC article.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
van der Watt ME, Reader J, Churchyard A, Nondaba SH, Lauterbach SB, Niemand J, Abayomi S, van Biljon RA, Connacher JI, van Wyk RDJ, Le Manach C, Paquet T, González Cabrera D, Brunschwig C, Theron A, Lozano-Arias S, Rodrigues JFI, Herreros E, Leroy D, Duffy J, Street LJ, Chibale K, Mancama D, Coetzer TL, Birkholtz LM. van der Watt ME, et al. J Antimicrob Chemother. 2018 May 1;73(5):1279-1290. doi: 10.1093/jac/dky008. J Antimicrob Chemother. 2018. PMID: 29420756
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites.
Wong HN, Padín-Irizarry V, van der Watt ME, Reader J, Liebenberg W, Wiesner L, Smith P, Eribez K, Winzeler EA, Kyle DE, Birkholtz LM, Coertzen D, Haynes RK. Wong HN, et al. Among authors: van der watt me. Front Chem. 2020 Jan 10;7:901. doi: 10.3389/fchem.2019.00901. eCollection 2019. Front Chem. 2020. PMID: 31998692 Free PMC article.
12 results