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Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target.
Verrier ER, Ligat G, Heydmann L, Doernbrack K, Miller J, Maglott-Roth A, Jühling F, El Saghire H, Heuschkel MJ, Fujiwara N, Hsieh SY, Hoshida Y, Root DE, Felli E, Pessaux P, Mukherji A, Mailly L, Schuster C, Brino L, Nassal M, Baumert TF. Verrier ER, et al. Among authors: heuschkel mj. Gut. 2022 Dec 9;72(9):1745-57. doi: 10.1136/gutjnl-2020-323665. Online ahead of print. Gut. 2022. PMID: 36591611 Free PMC article.
JAK1 promotes HDV replication and is a potential target for antiviral therapy.
Heuschkel MJ, Bach C, Meiss-Heydmann L, Gerges E, Felli E, Giannone F, Pessaux P, Schuster C, Lucifora J, Baumert TF, Verrier ER. Heuschkel MJ, et al. J Hepatol. 2024 Feb;80(2):220-231. doi: 10.1016/j.jhep.2023.10.030. Epub 2023 Nov 2. J Hepatol. 2024. PMID: 37925078 Free article.
A stable hepatitis D virus-producing cell line for host target and drug discovery.
Bach C, Lucifora J, Delphin M, Heydmann L, Heuschkel MJ, Pons C, Goto K, Scheers E, Schuster C, Durantel D, Pauwels F, Baumert TF, Verrier ER. Bach C, et al. Among authors: heuschkel mj. Antiviral Res. 2023 Jan;209:105477. doi: 10.1016/j.antiviral.2022.105477. Epub 2022 Nov 26. Antiviral Res. 2023. PMID: 36511319 Free article.