Fetal Renal DNA Methylation and Developmental Programming of Stress-Induced Hypertension in Growth-Restricted Male Mice.
DuPriest E, Hebert J, Morita M, Marek N, Meserve EEK, Andeen N, Houseman EA, Qi Y, Alwasel S, Nyengaard J, Morgan T.
DuPriest E, et al.
Reprod Sci. 2020 May;27(5):1110-1120. doi: 10.1007/s43032-019-00121-5. Epub 2020 Jan 1.
Reprod Sci. 2020.
PMID: 32046425
Free PMC article.
Progeny from TG dams were growth restricted with evidence of renal oxidative stress, males showed fetal renal DNA hypermethylation, they had fewer glomeruli, and they developed stress-induced hypertension as adults. Their female siblings did not share this pathology and in …
Progeny from TG dams were growth restricted with evidence of renal oxidative stress, males showed fetal renal DNA hypermethylation, they had …