Metallic Biomaterials: Current Challenges and Opportunities

Karthika Prasad; Olha Bazaka; Ming Chua; Madison Rochford; Liam Fedrick; Jordan Spoor; Richard Symes; Marcus Tieppo; Cameron Collins; Alex Cao; David Markwell; Kostya Ken Ostrikov; Kateryna Bazaka

doi:10.3390/ma10080884

Metallic Biomaterials: Current Challenges and Opportunities

Materials (Basel). 2017 Jul 31;10(8):884. doi: 10.3390/ma10080884.

Authors

Karthika Prasad^{1

2

3}, Olha Bazaka⁴, Ming Chua⁵, Madison Rochford⁶, Liam Fedrick⁷, Jordan Spoor⁸, Richard Symes⁹, Marcus Tieppo¹⁰, Cameron Collins¹¹, Alex Cao¹², David Markwell¹³, Kostya Ken Ostrikov^{14

15

16}, Kateryna Bazaka^{17

18

19

20}

Affiliations

¹ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. karthika.prasad@hdr.qut.edu.au.
² CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. karthika.prasad@hdr.qut.edu.au.
³ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. karthika.prasad@hdr.qut.edu.au.
⁴ College of Science and Engineering, Technology and Engineering, James Cook University, Townsville, QLD 4810, Australia. olga.bazaka@jcu.edu.au.
⁵ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. me.chua@connect.qut.edu.au.
⁶ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. madison.rochford@connect.qut.edu.au.
⁷ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. liam.fedrick@connect.qut.edu.au.
⁸ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. jordan.spoor@connect.qut.edu.au.
⁹ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. richard.symes@connect.qut.edu.au.
¹⁰ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. marcus.tieppo@connect.qut.edu.au.
¹¹ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. ck.collins@connect.qut.edu.au.
¹² School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. alex.cao@connect.qut.edu.au.
¹³ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. david.markwell@connect.qut.edu.au.
¹⁴ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. Kostya.ostrikov@qut.edu.au.
¹⁵ CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. Kostya.ostrikov@qut.edu.au.
¹⁶ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. Kostya.ostrikov@qut.edu.au.
¹⁷ School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia. kateryna.bazaka@qut.edu.au.
¹⁸ CSIRO-QUT Joint Sustainable Processes and Devices Laboratory, Commonwealth Scientific and Industrial Research Organization, P.O. Box 218, Lindfield, NSW 2070, Australia. kateryna.bazaka@qut.edu.au.
¹⁹ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia. kateryna.bazaka@qut.edu.au.
²⁰ College of Science and Engineering, Technology and Engineering, James Cook University, Townsville, QLD 4810, Australia. kateryna.bazaka@qut.edu.au.

Abstract

Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing.

Keywords: advanced materials; biomaterial; implant; inflammation; surface modification.

Publication types

Review