Objectives: Job satisfaction has been an essential element for the success of any organization, which has drawn the attention of several recent studies and policymakers. The aim of the current study was to investigate the impact of physical activities, self-efficacy and self-esteem on job satisfaction in manufacturing companies in Vietnam. The mediating impact of self-efficacy and self-esteem among physical activities and job satisfaction was also investigated. As a novel element, the study also examined the moderating impact of stress management among physical activities and job satisfaction in manufacturing companies in Vietnam. Methods: The study used survey questionnaires to gather the primary data from the selected employees of leading manufacturing companies of Vietnam. Using the PLS-SEM and Smart-PLS packages, the study analyzed the linkages among all variables. Results: The results revealed that physical activities, self-efficacy and self-esteem have a positive linkage with job satisfaction in manufacturing companies in Vietnam. The findings also exposed that self-efficacy and self-esteem significantly mediate among physical activities and job satisfaction. Conclusion: The findings also expressed that stress management significantly moderated between physical activities and job satisfaction. These findings will provide useful guidance and assistance to the strategists and policy makers to design policies related to job satisfaction using self-efficacy, stress management and self-esteem.