Abstract
Castleman's disease is a lymphoproliferative disorder characterized by angiofollicular lymph node hyperplasia. Recently, a new variant of multicentric Castleman's disease has been identified in Japan called TAFRO syndrome. It is characterized by a constellation of symptoms: thrombocytopenia, anasarca, reticulin fibrosis of the bone marrow, renal dysfunction and organomegaly (TAFRO). It is usually associated with polyclonal hyperimmunoglobulinemia. Here, we report the first and unique case of TAFRO syndrome with monoclonal gammapathy.
Keywords:
Castelman's disease; Gammapathie monoclonale; Maladie de Castelman; Monoclonal gammapathy; TAFRO syndrome.
Copyright © 2016 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Blood Protein Electrophoresis
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Castleman Disease / complications*
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Castleman Disease / diagnostic imaging
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Castleman Disease / drug therapy
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Castleman Disease / pathology
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Fever / etiology
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Hepatomegaly / etiology
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Humans
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Immunoglobulin G / blood*
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Immunoglobulin kappa-Chains / blood*
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Immunosuppressive Agents / therapeutic use
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Lymph Nodes / pathology
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Male
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Middle Aged
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Monoclonal Gammopathy of Undetermined Significance / blood
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Monoclonal Gammopathy of Undetermined Significance / drug therapy
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Monoclonal Gammopathy of Undetermined Significance / etiology*
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Rituximab / therapeutic use
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Splenomegaly / etiology
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Syndrome
Substances
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Immunoglobulin G
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Immunoglobulin kappa-Chains
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Immunosuppressive Agents
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Rituximab