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Effects of delayed versus immediate umbilical cord clamping in reducing death or major disability at 2 years corrected age among very preterm infants (APTS): a multicentre, randomised clinical trial.
Robledo KP, Tarnow-Mordi WO, Rieger I, Suresh P, Martin A, Yeung C, Ghadge A, Liley HG, Osborn D, Morris J, Hague W, Kluckow M, Lui K, Soll R, Cruz M, Keech A, Kirby A, Simes J; APTS Childhood Follow-up Study collaborators. Robledo KP, et al. Lancet Child Adolesc Health. 2022 Mar;6(3):150-157. doi: 10.1016/S2352-4642(21)00373-4. Epub 2021 Dec 8. Lancet Child Adolesc Health. 2022. PMID: 34895510 Clinical Trial.
Delayed versus Immediate Cord Clamping in Preterm Infants.
Tarnow-Mordi W, Morris J, Kirby A, Robledo K, Askie L, Brown R, Evans N, Finlayson S, Fogarty M, Gebski V, Ghadge A, Hague W, Isaacs D, Jeffery M, Keech A, Kluckow M, Popat H, Sebastian L, Aagaard K, Belfort M, Pammi M, Abdel-Latif M, Reynolds G, Ariff S, Sheikh L, Chen Y, Colditz P, Liley H, Pritchard M, de Luca D, de Waal K, Forder P, Duley L, El-Naggar W, Gill A, Newnham J, Simmer K, Groom K, Weston P, Gullam J, Patel H, Koh G, Lui K, Marlow N, Morris S, Sehgal A, Wallace E, Soll R, Young L, Sweet D, Walker S, Watkins A, Wright I, Osborn D, Simes J; Australian Placental Transfusion Study Collaborative Group. Tarnow-Mordi W, et al. N Engl J Med. 2017 Dec 21;377(25):2445-2455. doi: 10.1056/NEJMoa1711281. Epub 2017 Oct 29. N Engl J Med. 2017. PMID: 29081267 Free article. Clinical Trial.
To guide future practice, perinatal trials should be much larger, simpler and less fragile with close to 100% ascertainment of mortality and other key outcomes.
Tarnow-Mordi WO, Robledo K, Marschner I, Seidler L, Simes J; Australian Placental Transfusion Study (APTS) Childhood Follow Up Study Collaborators. Tarnow-Mordi WO, et al. Semin Perinatol. 2023 Aug;47(5):151789. doi: 10.1016/j.semperi.2023.151789. Epub 2023 Jun 11. Semin Perinatol. 2023. PMID: 37422415