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Page 1
Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease.
Hum Mol Genet. 2023 May 18;32(11):1888-1900. doi: 10.1093/hmg/ddad025.
Hum Mol Genet. 2023.
PMID: 36752535
Free PMC article.
mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells.
Brown RA, Voit A, Srikanth MP, Thayer JA, Kingsbury TJ, Jacobson MA, Lipinski MM, Feldman RA, Awad O.
Brown RA, et al. Among authors: srikanth mp.
Dis Model Mech. 2019 Oct 16;12(10):dmm038596. doi: 10.1242/dmm.038596.
Dis Model Mech. 2019.
PMID: 31519738
Free PMC article.
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Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein.
Gould NR, Williams KM, Joca HC, Torre OM, Lyons JS, Leser JM, Srikanth MP, Hughes M, Khairallah RJ, Feldman RA, Ward CW, Stains JP.
Gould NR, et al. Among authors: srikanth mp.
Elife. 2021 Mar 29;10:e64393. doi: 10.7554/eLife.64393.
Elife. 2021.
PMID: 33779549
Free PMC article.
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Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition.
Panicker LM, Srikanth MP, Castro-Gomes T, Miller D, Andrews NW, Feldman RA.
Panicker LM, et al. Among authors: srikanth mp.
Hum Mol Genet. 2018 Mar 1;27(5):811-822. doi: 10.1093/hmg/ddx442.
Hum Mol Genet. 2018.
PMID: 29301038
Free PMC article.
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Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation.
Awad O, Panicker LM, Deranieh RM, Srikanth MP, Brown RA, Voit A, Peesay T, Park TS, Zambidis ET, Feldman RA.
Awad O, et al. Among authors: srikanth mp.
Stem Cell Reports. 2017 Dec 12;9(6):1853-1867. doi: 10.1016/j.stemcr.2017.10.029. Epub 2017 Nov 30.
Stem Cell Reports. 2017.
PMID: 29198828
Free PMC article.
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Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1.
Srikanth MP, Jones JW, Kane M, Awad O, Park TS, Zambidis ET, Feldman RA.
Srikanth MP, et al.
Stem Cells Transl Med. 2021 Jul;10(7):1081-1094. doi: 10.1002/sctm.20-0386. Epub 2021 Mar 3.
Stem Cells Transl Med. 2021.
PMID: 33656802
Free PMC article.
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Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease.
Srikanth MP, Feldman RA.
Srikanth MP, et al.
Biomolecules. 2020 Dec 3;10(12):1630. doi: 10.3390/biom10121630.
Biomolecules. 2020.
PMID: 33287247
Free PMC article.
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