Abstract
A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3. The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells. The results revealed that the studied compounds 4 have low or no antitumor activity towards EAC tumor cells.
MeSH terms
-
Animals
-
Antibiotics, Antineoplastic / therapeutic use
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / pharmacology*
-
Carcinoma, Ehrlich Tumor / drug therapy
-
Carcinoma, Ehrlich Tumor / pathology
-
Cell Line, Tumor
-
Doxorubicin / therapeutic use
-
Drug Screening Assays, Antitumor
-
Indicators and Reagents
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Mice
-
Pyrimidinones / chemical synthesis*
-
Pyrimidinones / pharmacology*
-
Spectrophotometry, Infrared
-
Triazoles / chemical synthesis*
-
Triazoles / pharmacology*
Substances
-
Antibiotics, Antineoplastic
-
Antineoplastic Agents
-
Indicators and Reagents
-
Pyrimidinones
-
Triazoles
-
Doxorubicin