Newly synthesized water soluble cholinium-purpurin photosensitizers and their stabilized gold nanoparticles as promising anticancer agents

Dorjnamjin Demberelnyamba; Mama Ariunaa; Young Key Shim

doi:10.3390/ijms9050864

Newly synthesized water soluble cholinium-purpurin photosensitizers and their stabilized gold nanoparticles as promising anticancer agents

Int J Mol Sci. 2008 May;9(5):864-871. doi: 10.3390/ijms9050864. Epub 2008 May 23.

Authors

Dorjnamjin Demberelnyamba¹, Mama Ariunaa¹, Young Key Shim¹

Affiliation

¹ PDT Research Institute, School of Nano System Engineering, Inje University, Gimhae, Korea.

Abstract

For possible future use in Photodynamic Therapy (PDT) and/or Photothermal Therapy (PTT) of cancer and screening of cancer cells a new type of ionic liquid photosensitizer -Cholinium-Purpurin-18 (Chol-Pu-18) - was synthesized and small gold (Au) nanoparticles, stabilized by this photosensitizer were prepared without adding any particular reducing agents and CTAB. UV-Vis spectroscopy and Transmission Electron Microscopy (TEM) were used for characterization of the nanoparticles and FAB-MS and NMR of the ionic liquid choline hydroxide, purpurin carboxylate and their ionic liquid type of photosensitizer were obtained.

Keywords: Ionic liquid type photosensitizers; anticancer agents; choline; cholinium-purpurin-18; gold nanoparticles; purpurin-18.