A new synthetic route for the total synthesis of dendrodolide-L has been developed from known chiral epoxides. The key reactions involved in this synthesis are regioselective ring-opening of epoxide, Yamaguchi esterification and ring-closing metathesis reactions (RCM) to result the target compound.
Keywords: Dendrodolide-L; Yamaguchi esterification and ring-closing metathesis; ozonolysis.