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Mapping the landscape of genetic dependencies in chordoma.
Sharifnia T, Wawer MJ, Goodale A, Lee Y, Kazachkova M, Dempster JM, Muller S, Levy J, Freed DM, Sommer J, Kalfon J, Vazquez F, Hahn WC, Root DE, Clemons PA, Schreiber SL. Sharifnia T, et al. Nat Commun. 2023 Apr 6;14(1):1933. doi: 10.1038/s41467-023-37593-8. Nat Commun. 2023. PMID: 37024492 Free PMC article.
Similar compounds searching system by using the gene expression microarray database.
Toyoshiba H, Sawada H, Naeshiro I, Horinouchi A. Toyoshiba H, et al. Toxicol Lett. 2009 Apr 10;186(1):52-7. doi: 10.1016/j.toxlet.2008.08.009. Epub 2008 Aug 29. Toxicol Lett. 2009. PMID: 18801419
., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S.A., Haggarty, S.J., Clemons, P.A., Wei, R., Carr, S.A., Lander, E.S., Golub, T.R., 200 …
., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., Re …
HOXA13 in etiology and oncogenic potential of Barrett's esophagus.
Janmaat VT, Nesteruk K, Spaander MCW, Verhaar AP, Yu B, Silva RA, Phillips WA, Magierowski M, van de Winkel A, Stadler HS, Sandoval-Guzmán T, van der Laan LJW, Kuipers EJ, Smits R, Bruno MJ, Fuhler GM, Clemons NJ, Peppelenbosch MP. Janmaat VT, et al. Nat Commun. 2021 Jun 7;12(1):3354. doi: 10.1038/s41467-021-23641-8. Nat Commun. 2021. PMID: 34099670 Free PMC article.
Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity.
Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, Schreiber SL, Workman P, Young RA, Lin CY. Sheppard HE, et al. Cell Rep Med. 2021 Jan 19;2(1):100188. doi: 10.1016/j.xcrm.2020.100188. eCollection 2021 Jan 19. Cell Rep Med. 2021. PMID: 33521702 Free PMC article.
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors.
Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, Kaemmerer D, Karan C, Kidd M, Kim KM, Kim HC, Kunju LP, Langel Ü, Li Z, Lee J, Li H, LiVolsi V, Pfragner R, Rainey AR, Realubit RB, Remotti H, Regberg J, Roses R, Rustgi A, Sepulveda AR, Serra S, Shi C, Yuan X, Barberis M, Bergamaschi R, Chinnaiyan AM, Detre T, Ezzat S, Frilling A, Hommann M, Jaeger D, Kim MK, Knudsen BS, Kung AL, Leahy E, Metz DC, Milsom JW, Park YS, Reidy-Lagunes D, Schreiber S, Washington K, Wiedenmann B, Modlin I, Califano A. Alvarez MJ, et al. Nat Genet. 2018 Jul;50(7):979-989. doi: 10.1038/s41588-018-0138-4. Epub 2018 Jun 18. Nat Genet. 2018. PMID: 29915428 Free PMC article.