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Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties.
Ziemniak M, Kowalska J, Lukaszewicz M, Zuberek J, Wnek K, Darzynkiewicz E, Jemielity J. Ziemniak M, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5369-81. doi: 10.1016/j.bmc.2015.07.052. Epub 2015 Jul 29. Bioorg Med Chem. 2015. PMID: 26264844
The synthesis and biochemical properties of 17 new mRNA cap analogues are reported. Six of these nucleotides are m(7)GTP derivatives, whereas 11 are 'two headed' tetraphosphate dinucleotides based on a m(7)Gppppm(7)G structure. ...The compounds were prepared by diva …
The synthesis and biochemical properties of 17 new mRNA cap analogues are reported. Six of these nucleotides are m(7)GTP derivatives, …
Inequality and ethics in paediatric HIV remission research: From Mississippi to South Africa and back.
Crane JT, Rossouw TM. Crane JT, et al. Glob Public Health. 2017 Feb;12(2):220-235. doi: 10.1080/17441692.2016.1211162. Epub 2016 Jul 25. Glob Public Health. 2017. PMID: 27458074 Free PMC article.
In 2013, physician-researchers announced that a baby in Mississippi had been 'functionally cured' of HIV [Persaud, D., Gay, H., Ziemniak, C. F., Chen, Y. H., Piatak, M., Chun, T.-W., Luzuriaga, K. (2013b, March). ...
In 2013, physician-researchers announced that a baby in Mississippi had been 'functionally cured' of HIV [Persaud, D., Gay, H., Ziemniak …
Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex.
Ziemniak M, Mugridge JS, Kowalska J, Rhoads RE, Gross JD, Jemielity J. Ziemniak M, et al. RNA. 2016 Apr;22(4):518-29. doi: 10.1261/rna.055152.115. Epub 2016 Jan 29. RNA. 2016. PMID: 26826132 Free PMC article.
The molecular details of Dcp1/2 catalysis remain elusive, in part because both cap substrate (m(7)GpppN) and m(7)GDP product are bound by Dcp1/2 with weak (mM) affinity. ...One of the most potent cap analogs, m(7)GpSpppSm(7)G, inhibited Dcp1/2 20 times more e …
The molecular details of Dcp1/2 catalysis remain elusive, in part because both cap substrate (m(7)GpppN) and m(7)GDP product a …
High-performance liquid chromatographic determination of metoprolol and alpha-hydroxymetoprolol concentrations in human serum, urine, and cerebrospinal fluid.
Gengo FM, Ziemniak MA, Kinkel WR, McHugh WB. Gengo FM, et al. J Pharm Sci. 1984 Jul;73(7):961-3. doi: 10.1002/jps.2600730725. J Pharm Sci. 1984. PMID: 6470961
Following protein precipitation with trichloroacetic acid, the sample was alkalinized with 1 M NaOH and extracted with dichloromethane. The mobile phase consisted of acetonitrile-water (50:50) containing 0.005 M 1-heptanesulfonic acid in 0.001% acetic acid. ...
Following protein precipitation with trichloroacetic acid, the sample was alkalinized with 1 M NaOH and extracted with dichloromethan …
Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation.
Kowalska J, Lukaszewicz M, Zuberek J, Ziemniak M, Darzynkiewicz E, Jemielity J. Kowalska J, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1921-5. doi: 10.1016/j.bmcl.2009.02.053. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19269171
We report synthesis and properties of a pair of new potent inhibitors of translation, namely two diastereomers of 7-methylguanosine 5'-(1-thiotriphosphate). These new analogs of mRNA 5'cap (referred to as m(7)GTPalphaS (D1) and (D2)) are recognized by translational factor …
We report synthesis and properties of a pair of new potent inhibitors of translation, namely two diastereomers of 7-methylguanosine 5'-(1-th …
[Diagnosis and treatment of thyroid cancer in children in the multicenter analysis in Poland for PPGGL].
Prokurat AI, Chrupek M, Pacholska M, Gałazka P, Harasymczuk J, Jankowski A, Niedziela M, Korman E, Kozłowicz-Gudzińska I, Czetwertyńska M, Kaliciński P, Polnik D, Starzyk J, Kalicka-Kasperczyk A, Czernik J, Sawicz-Birkowska K, Bagłaj M, Balcerska A, Stefanowicz J, Birkholz D, Pomorski L, Kaczka K, Peregud-Pogorzelski J, Petriczko E, Godziński J, Ptaszyńska J, Ziemniak B, Woźniak W, Bilska K, Górska M, Zonenberg A. Prokurat AI, et al. Endokrynol Pol. 2006;57 Suppl A:75-81. Endokrynol Pol. 2006. PMID: 17091461 Polish.
11 results