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Metronidazole esters: a new class of antiglycation agents.
Zeb A, Malik I, Rasheed S, Choudhary MI, Basha FZ. Zeb A, et al. Among authors: malik i. Med Chem. 2012 Sep;8(5):846-52. doi: 10.2174/157340612802084360. Med Chem. 2012. PMID: 22741779
The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28, 16, and 3 have IC(50) values 218.97 2.5, 245.3 5.1, and 278.6 0.8 M, respectively, comparable to the standard agent, rutin (IC(50) = 294.5 1.50 M). ...
The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28, 16, and 3 have IC(50) values 218.97 2.5, 24 …
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Famulla K, Sass P, Malik I, Akopian T, Kandror O, Alber M, Hinzen B, Ruebsamen-Schaeff H, Kalscheuer R, Goldberg AL, Brötz-Oesterhelt H. Famulla K, et al. Among authors: malik i. Mol Microbiol. 2016 Jul;101(2):194-209. doi: 10.1111/mmi.13362. Epub 2016 Apr 1. Mol Microbiol. 2016. PMID: 26919556 Free PMC article.
Here we show that, in contrast, mycobacteria are killed by ADEP through inhibition of ClpP function. Although ADEPs can stimulate purified M. tuberculosis ClpP1P2 to degrade larger peptides and unstructured proteins, this effect is weaker than for ClpP from other bacteria …
Here we show that, in contrast, mycobacteria are killed by ADEP through inhibition of ClpP function. Although ADEPs can stimulate purified …
Primary perisplenic hydatid cyst.
Sharif MA, Mahmood A, Murtaza B, Malik IB, Khan A, Asghar Z, Arif A. Sharif MA, et al. Among authors: malik ib. J Coll Physicians Surg Pak. 2009 Jun;19(6):380-2. J Coll Physicians Surg Pak. 2009. PMID: 19486579