Suppression of human lysozyme aggregation by a novel copper-based complex of 3,4-dimethoxycinnamic acid.
Dilshad S, Shabnam, Ali A, Firdaus S, Ahmad M, Ahmad A.
Dilshad S, et al.
J Biomol Struct Dyn. 2023 Aug 14:1-13. doi: 10.1080/07391102.2023.2246567. Online ahead of print.
J Biomol Struct Dyn. 2023.
PMID: 37578054
The fluorescence titration studies showed moderate binding interaction of 1 with HuL with Ka of 6.3x10(5) M(-1) at pH-2, 25 C due to its interaction withAsp53, Tyr63, Val110, and Ala111 as shown by docking and simulation studies. 1suppresses the HuL fibrillation in a conce …
The fluorescence titration studies showed moderate binding interaction of 1 with HuL with Ka of 6.3x10(5) M(-1) at pH-2, 25 C due to …