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Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells.
Al-Sanea MM, Al-Ansary GH, Elsayed ZM, Maklad RM, Elkaeed EB, Abdelgawad MA, Bukhari SNA, Abdel-Aziz MM, Suliman H, Eldehna WM. Al-Sanea MM, et al. J Enzyme Inhib Med Chem. 2021 Dec;36(1):987-999. doi: 10.1080/14756366.2021.1915302. J Enzyme Inhib Med Chem. 2021. PMID: 33985397 Free PMC article.
This study reports the synthesis and in vitro biological assessment of two sets of 3-methylbenzofurans (4a-d, 6a-c, 8a-c and 11) and 3-(morpholinomethyl)benzofurans (15a-c, 16a-b, 17a-b and 18) as potential anticancer agents towards non-small cell lung carcinoma A549 and N …
This study reports the synthesis and in vitro biological assessment of two sets of 3-methylbenzofurans (4a-d, 6a-c, 8a-c and 11) and …
Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation.
Eldehna WM, Abo-Ashour MF, Ibrahim HS, Al-Ansary GH, Ghabbour HA, Elaasser MM, Ahmed HYA, Safwat NA. Eldehna WM, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):686-700. doi: 10.1080/14756366.2017.1421181. J Enzyme Inhib Med Chem. 2018. PMID: 29560733 Free PMC article.
SAR studies unravelled that N-propylindole derivatives were the most active compounds such as 6n (MCF-7; IC(50)=1.04 M), which displayed a significant decrease of cell population in the G2/M phase and significant increase in the early and late apoptosis by 19-folds …
SAR studies unravelled that N-propylindole derivatives were the most active compounds such as 6n (MCF-7; IC(50)=1.04 M), which displa …