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Apolipoprotein A1 Infusions and Cardiovascular Outcomes after Acute Myocardial Infarction.
Gibson CM, Duffy D, Korjian S, Bahit MC, Chi G, Alexander JH, Lincoff AM, Heise M, Tricoci P, Deckelbaum LI, Mears SJ, Nicolau JC, Lopes RD, Merkely B, Lewis BS, Cornel JH, Trebacz J, Parkhomenko A, Libby P, Sacks FM, Povsic TJ, Bonaca M, Goodman SG, Bhatt DL, Tendera M, Steg PG, Ridker PM, Aylward P, Kastelein JJP, Bode C, Mahaffey KW, Nicholls SJ, Pocock SJ, Mehran R, Harrington RA; AEGIS-II Committees and Investigators. Gibson CM, et al. N Engl J Med. 2024 May 2;390(17):1560-1571. doi: 10.1056/NEJMoa2400969. Epub 2024 Apr 6. N Engl J Med. 2024. PMID: 38587254 Clinical Trial.
Synthesis of oligoribonucleotides with phosphonate-modified linkages.
Páv O, Košiová I, Barvík I, Pohl R, Buděšínský M, Rosenberg I. Páv O, et al. Org Biomol Chem. 2011 Sep 7;9(17):6120-6. doi: 10.1039/c1ob05488k. Epub 2011 Jul 18. Org Biomol Chem. 2011. PMID: 21769370
The introduction of the 5'-phosphonate units resulted in moderate destabilisation of the RNA/RNA duplexes (deltaT(m)-1.8 C/mod.), whereas the introduction of the 3'-phosphonate units resulted in considerable destabilisation of the duplexes (deltaT(m)-5.7 C/mod.). .. …
The introduction of the 5'-phosphonate units resulted in moderate destabilisation of the RNA/RNA duplexes (deltaT(m)-1.8 C/mod.), whe …
Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides.
Pícha J, Buděšínský M, Mitrová K, Jiráček J. Pícha J, et al. Chempluschem. 2020 Jun;85(6):1297-1306. doi: 10.1002/cplu.202000246. Chempluschem. 2020. PMID: 32558358
These ester linkers are acid-stable and resistant to the base-mediated diketopiperazine formation that often occurs during the synthesis of ester-bound peptides; they are stable at neutral pH in aqueous buffers for days but can be effectively cleaved with 0.1 m NaOH or aq. …
These ester linkers are acid-stable and resistant to the base-mediated diketopiperazine formation that often occurs during the synthesis of …
Chimerical pyrene-based [7]helicenes as twisted polycondensed aromatics.
Buchta M, Rybáček J, Jančařík A, Kudale AA, Buděšínský M, Chocholoušová JV, Vacek J, Bednárová L, Císařová I, Bodwell GJ, Starý I, Stará IG. Buchta M, et al. Chemistry. 2015 Jun 8;21(24):8910-7. doi: 10.1002/chem.201500826. Epub 2015 Apr 29. Chemistry. 2015. PMID: 25925496
Chimerical pyrene-based dibenzo[7]helicene rac-1 and 2H-pyran[7]helicene (M,R,R)-(-)-2, in which two pyrene subunits are fused to the [7]helicene/[7]heterohelicene scaffold, were synthesised by means of Ni(0) - or Co(I) -mediated [2+2+2] cycloisomerisation of dipyrenyl-ace …
Chimerical pyrene-based dibenzo[7]helicene rac-1 and 2H-pyran[7]helicene (M,R,R)-(-)-2, in which two pyrene subunits are fused to the …
Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp.
Kočendová J, Vaňková E, Volejníková A, Nešuta O, Buděšínský M, Socha O, Hájek M, Hadravová R, Čeřovský V. Kočendová J, et al. FEMS Yeast Res. 2019 May 1;19(3):foz013. doi: 10.1093/femsyr/foz013. FEMS Yeast Res. 2019. PMID: 30753486
The lowest minimum inhibitory concentration (MIC90) of LL-III/43 was observed towards Candida tropicalis (0.8 M). That was 8-fold lower than that of antimycotic amphotericin B. ...Biofilm inhibitory concentrations (BIC50) ranged from 0.9 to 58.6 M and biofilm eradic …
The lowest minimum inhibitory concentration (MIC90) of LL-III/43 was observed towards Candida tropicalis (0.8 M). That was 8-fold low …
Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Novotná B, Holá L, Staś M, Gutten O, Smola M, Zavřel M, Vavřina Z, Buděšínský M, Liboska R, Chevrier F, Dobiaš J, Boura E, Rulíšek L, Birkuš G. Novotná B, et al. Biochemistry. 2021 Dec 7;60(48):3714-3727. doi: 10.1021/acs.biochem.1c00692. Epub 2021 Nov 17. Biochemistry. 2021. PMID: 34788017
QM/MM identified three outliers (mostly homodimers) for which we have no clear explanation of their impaired binding with respect to their heterodimeric counterparts, whereas the R(2) = 0.7 correlation between the computed deltaG'(int_rel) and experimental deltaT(m)'s for …
QM/MM identified three outliers (mostly homodimers) for which we have no clear explanation of their impaired binding with respect to their h …
A γ-cyclodextrin duplex connected with two disulfide bonds: synthesis, structure and inclusion complexes.
Volkov S, Kumprecht L, Buděšínský M, Lepšík M, Dušek M, Kraus T. Volkov S, et al. Org Biomol Chem. 2015 Mar 14;13(10):2980-5. doi: 10.1039/c4ob02464h. Org Biomol Chem. 2015. PMID: 25616110
Due to this large inner space the duplex forms very stable inclusion complexes with steroids; bile acids examined in this study show binding affinities to the gamma-cyclodextrin duplex in the range of 5.3 10(7) M(-1)-1.9 10(8) M(-1)....
Due to this large inner space the duplex forms very stable inclusion complexes with steroids; bile acids examined in this study show binding …
Invasive Hemodynamic Assessment of Cardiac Output State after MitraClip Therapy in Nonanaesthetized Patients with Functional Mitral Regurgitation.
Bednar F, Budesinsky T, Linkova H, Kocka V. Bednar F, et al. Biomed Res Int. 2016;2016:6296972. doi: 10.1155/2016/6296972. Epub 2016 Dec 12. Biomed Res Int. 2016. PMID: 28058260 Free PMC article. Clinical Trial.

Mitral valve clipping significantly increased cardiac index (CI) (from 2.0 0.5 to 3.3 0.6 L/min/m(2); p < 0.01). Conversely, there was significant reduction in the mean pulmonary capillary wedge pressure (PCWP) (from 18.6 5.7 to 10.5 3.8 mmHg; p < 0.01), mean pulmona

Mitral valve clipping significantly increased cardiac index (CI) (from 2.0 0.5 to 3.3 0.6 L/min/m(2); p < 0.01). Conversely, there

Novel isosteric, isopolar phosphonate analogs of oligonucleotides: preparation and properties.
Tocík Z, Barvík I Jr, Budesínský M, Rosenberg I. Tocík Z, et al. Biopolymers. 2006 Nov;83(4):400-13. doi: 10.1002/bip.20571. Biopolymers. 2006. PMID: 16845669
The fully modified homooligomers did not hybridize while homooligomers with alternating sequences containing alpha-L-threo-configured units (but not beta-D-erythro-) showed a significant decrease in T(m) values in comparison with natural dT(15). For a comparative study, ph …
The fully modified homooligomers did not hybridize while homooligomers with alternating sequences containing alpha-L-threo-configured units …
Rigid duplex alpha-cyclodextrin reversibly connected with disulfide bonds. Synthesis and inclusion complexes.
Kumprecht L, Budesínský M, Vondrásek J, Vymetal J, Cerný J, Císarová I, Brynda J, Herzig V, Koutník P, Závada J, Kraus T. Kumprecht L, et al. J Org Chem. 2009 Feb 6;74(3):1082-92. doi: 10.1021/jo802139s. J Org Chem. 2009. PMID: 19113826
The stability constants of the complexes gradually increase with the alkyl chain length and reach an unprecedently high value of K = 8.6 x 10(9) M(-1) for 1,14-tetradecanediol. It was found that the doubly bridged dimer 6 exhibits higher binding affinity toward the series …
The stability constants of the complexes gradually increase with the alkyl chain length and reach an unprecedently high value of K = 8.6 x 1 …
17 results